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TranscriptomicsActivation of STAT6 by STING Is Critical for Antiviral Innate Immunity
Analysis of the transcriptional response of HEK293 or HEK293-STAT6 stable cell lines to poly(I:C) transfection. The hypothesis tested was that poly(I:C) transfection is capable of inducing the expression of STAT6-dependent antiviral genes. mRNA isolated from HEK293 or HEK293-STAT6 stable cell lines ...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-26435 | biostudies-arrayexpress
ProteomicsSirtuin 5-mediated desuccinylation of ALDH2 alleviates mitochondrial oxidative stress following acetaminophen-induced acute liver injury
WT mice and SIRT5 knockout mice were injected with APAP by intraperitoneal injection, and liver tissue specimens were taken 24 hours later for protein succinylation modification histology analysis
ORGANISM(S): Mus Musculus 
2024-02-24 | PXD050121 |
ProteomicsNovel Insights into Candidate Biomarkers in Patients with Chronic Mountain Sickness Based on Proteomics
Chronic mountain sickness (CMS) is a progressive incapacitating syndrome induced by lifelong exposure to hypoxia. In the present study, proteomic analysis was used to identify the differential expression proteins (DEPs) and then evaluate the potential biomarkers between CMS and non-CMS groups. A tot...
ORGANISM(S): Homo Sapiens 
2020-10-22 | PXD022139 |
ProteomicsCellular and Comparative Proteomic Analyses Reveal Developmental Differences in Anthers at Meiosis between Diploid and Autotetraploid Rice
Newly synthetic autotetraploid rice generally shows lower pollen fertility and seed setting rate in comparison to diploid rice, and this can hinder its own domestication and breeding. In this study, cytological analysis was used to demonstrate the imbalanced separation of homologous chromosomes occu...
ORGANISM(S): Oryza Sativa 
PXD033183 |
ProteomicsThyroid cancer ATC-PDTC-PTC-N FFPE 4D-DIA proteomics
We performed 4D-DIA proteomic profiling on formalin-fixed paraffin-embedded (FFPE) thyroid tissues, covering anaplastic thyroid carcinoma (ATC), poorly differentiated thyroid carcinoma (PDTC), papillary thyroid carcinoma (PTC), and matched normal (N) controls. Using the timsTOF Pro platform with ion...
ORGANISM(S): Homo Sapiens 
2025-12-21 | PXD068266 |
ProteomicsAnalysis of protein interaction between human platelets and SARS-CoV-2 envelope protein
Analysis of protein interaction between platelets and SARS-CoV-2 envelope protein
ORGANISM(S): Homo Sapiens Severe Acute Respiratory Syndrome Coronavirus 2 
PXD037073 |
ProteomicsPRMT3 reverses HIV-1 latency by increasing chromatin accessibility to form a TEAD4-P-TEFb-containing transcriptional hub
A major challenge to the current efforts to cure HIV-1 infection is the persistence of latent viruses. Addressing this challenge hinges on unraveling the intricate interplay between the host and viral factors that are key for HIV-1 latency. Current antiretroviral agents effectively prevent actively ...
ORGANISM(S): Homo Sapiens 
2025-03-25 | PXD062187 |
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