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ProteomicsAnalysis of reconstituted tripartite complex supports avidity-based recruitment of Hsp70 by substrate bound J-domain protein
Hsp70 are ubiquitous, versatile molecular chaperones that cyclically interact with substrate protein(s). The initial step requires synergistic interaction of a substrate and a J-domain protein (JDP) cochaperone, via its J-domain, with Hsp70 to stimulate hydrolysis of its bound ATP. This hydrolysis d...
ORGANISM(S): Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2024-02-19 | PXD044739 | Pride
Hsc20 Hsp70 atpase cycle Substrate delivery Ssq1 Molecular chaperones 
ProteomicsPreparation of the RecJ3/4-RNase J complex from Haloferax volcanii
Purification of RecJ3/4-RNase J complex from Haloferax.volcanii
ORGANISM(S): Haloferax volcanii DS2 
2023-06-22 | PXD019898 | Pride
Recj4 Recj3 Rnasej 
ProteomicsRNase J, RecJ3, RNase J, RecJ3, Cdc48a and Cas7 co-purify with RecJ4-StrepII in the presence of γATP. and Cas7 co-purify with RecJ4-StrepII in the presence of γATP.
detecting core complex formation for RecJ3/4 and RNase J form a core complex.
ORGANISM(S): Haloferax volcanii DS2 
2023-06-22 | PXD019932 | Pride
Recj4 and cdc48a Recj3 
ProteomicsRNAseJ pull down to identify associated proteins
RNAse J, HVO_2724 from halophilic archaeon to identify the proteins it associates with
ORGANISM(S): Haloferax volcanii DS2 
2023-06-22 | PXD019896 | Pride
Rnase j Haloferax volcanii Hvo_2724 
ProteomicsRBM39 organizes an m⁶A-dependent silencing complex to degrade Tat mRNA and maintain HIV-1 latency
Given the pivotal role of Tat in HIV-1 latency, we performed RNA pull-down assays in latently HIV-1-infected J-Lat 10.6 cells using biotinylated RNA probes (including a control RNA probe and a Tat-specific RNA probe) . Cell lysates were incubated with streptavidin agarose resin pre-bound to Tat RNA ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-31 | PXD064834 | Pride
Lc/ms Tat Rip J-lat 10.6 
TranscriptomicsDietary folate depletion and repletion in A/J and C57BL/6J mice
Defects in homocysteine and folate metabolism are associated with increased risks for neural tube and congenital heart defects, cardiovascular disease and stroke, cancers, and neurodegeneration. In many but not all cases, dietary supplementation with folate significantly reduces the severity and in...
ORGANISM(S): Mus musculus 
2008-08-27 | E-GEOD-9242 | biostudies-arrayexpress
TranscriptomicsGene expression in epithelial and non-epithelial cells of renal origin
We aimed to define epithelial-specific genes in the kidney. In the developing mouse kidney at E12.5 epithelial cells are restricted to the ureteric bud, while mesenchymal cells surrounding the ureteric bud are non-epithelial. The mouse renal epithelial cell line mIMCD-3 was used to represent kidney ...
ORGANISM(S): Mus musculus 
2010-09-23 | E-GEOD-24295 | biostudies-arrayexpress
ProteomicsNUDCD3 deficiency disrupts V(D)J recombination to cause SCID/Omenn syndrome
Inborn errors of T cell development present a pediatric emergency in which timely curative therapy is informed by molecular diagnosis. In 9 affected patients across 3 consanguineous kindreds, we detected homozygosity for a single deleterious missense variant in the gene NudC domain containing 3 (NUD...
ORGANISM(S): Homo sapiens (Human) 
2024-09-27 | PXD035840 | Pride
Pulldown Nudcd3 Proteomics Omenn syndrome 
MetabolomicsThe Manchurian Walnut Genome: Insights into Juglone and Lipid Biosynthesis

BACKGROUND: Manchurian walnut (Juglans mandshurica Maxim.) is a tree with multiple industrial uses and medicinal properties in the Juglandaceae family (walnuts and hickories). J. mandshurica produces juglone, which is a toxic allelopathic agent and has potential utilization value...

2022-05-18 | MTBLS3657 | MetaboLights
UnknownMicroRNA-23b Promotes Avian Leukosis Virus Subgroup J (ALV-J) Replication by Targeting IRF1.
Not available
S-EPMC4434839 | biostudies-literature
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