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UnknownAndrogen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish.
Testosterone is closely associated with lipid metabolism and known to affect body fat composition and muscle mass in males. However, the mechanisms by which testosterone acts on lipid metabolism are not yet fully understood, especially in teleosts. In this study, cyp17a1-/- zebrafish ( Dan...
S-EPMC11017085 | biostudies-literature
UnknownCompound bioengineering protein supplementation improves intestinal health and growth performance of broilers.
Currently, antimicrobial peptides (AMPs) are of growing interest as potential substitutes for antibiotic growth promoters in animal production. The present study was conducted to evaluate the effects of dietary supplementation of bioengineering artificial Parasin I protein (API) and artificial plect...
S-EPMC10480649 | biostudies-literature
UnknownCell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity.

Background

The astrocytes in the central nervous system (CNS) exhibit morphological and functional diversity in brain region-specific pattern. Functional alterations of reactive astrocytes are commonly present in human temporal lobe epilepsy (TLE) cases, meanwhile the neuroinflammation media...
S-EPMC10601220 | biostudies-literature
ProteomicsProteomic analysis of Emx1-G6PD CKO mouse cortex
To identify differentially expressed proteins in the cerebral cortex between control and Emx1-G6PD CKO mice
ORGANISM(S): Mus Musculus 
PXD066386 |
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
UnknownObligate mutualism within a host drives the extreme specialization of a fig wasp genome.

Background

Fig pollinating wasps form obligate symbioses with their fig hosts. This mutualism arose approximately 75 million years ago. Unlike many other intimate symbioses, which involve vertical transmission of symbionts to host offspring, female fig wasps fly great distances to transfer h...
S-EPMC4053974 | biostudies-literature
UnknownEmerging tobacco-related cancer risks in China: A nationwide, prospective study of 0.5 million adults.

Background

In China, cigarette consumption has increased substantially since the 1980s, almost exclusively in men. This study was aimed at assessing the emerging cancer risks.

Methods

A nationwide, prospective study recruited 210,259 men and 302,632 women aged 30 to 79 years from 10 a...
S-EPMC4584499 | biostudies-literature
Genomicsena-DATASET-GoT2D/T2D-GENES-09-07-2016-02:03:47:226-1135 - samples
The GoT2D study includes ~2800 samples, half T2D cases and half T2D controls, of Northern European ancestry sequenced over 3 three technologies: deep whole exome sequencing, low-pass (4x) whole genome sequencing, and OMNI 2.5M genotyping. Samples were ascertained to be phenotypically "extreme" (e.g....
EGAD00001002247 | EGA
GenomicsImputation analysis file
This data set includes the following summary level data file used for the imputation data: imputation.sv.assoc.txt: results from single variant association analysis in imputed samples
EGAD00010001184 | EGA
Genomics13K T2D-GENES analysis files
This data set includes the following summary level data files used for the 13k analysis of T2D-GENES data: wes.variants.list: list of variants to keep for any analysis of the exomes data wes.assoc.samples.list: list of samples to keep for association analysis wes.assoc.variants.list: list of variant...
EGAD00010001188 | EGA
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