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ProteomicsSystematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS sensing pathway
Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the steady-state levels of cellular reactive oxygen species (ROS). However, for most of these drugs exactly how the resultant ROS function and are sensed is poorly understood. It remains unclear which proteins t...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD041138 | Pride
Chermoresistance  redox signaling Ros  chemical proteomics  organelle signaling  chemotherapy 
ProteomicsComparative proteomic and clinicopathlogical analysis of breast adenoid cystic carcinoma and basal-like triple-negative breast cancer
We applied mass spectrometry-based quantitative proteomics to analyze the protein expression in paired tumor and adjacent normal breast tissue of five ACC and five BL-TNBC. Bioinformatic analyses and the clinicopathological information including histologic features, immunohistochemistry and FISH wer...
ORGANISM(S): Homo Sapiens 
2022-05-16 | PXD033928 |
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