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GenomicsERM-NM-1 and PolII ChIP seq from Mouse Uterus
To advance understanding of mechanisms leading to biological and transcriptional endpoints related to estrogen action in the mouse uterus, we have mapped ERM-NM-1 and RNA polymerase II binding sites using chromatin immunoprecipitation (ChIP) followed by sequencing of enriched chromatin fragments (Ch...
ORGANISM(S): Mus musculus 
2012-04-08 | E-GEOD-36455 | biostudies-arrayexpress
TranscriptomicsHigh-throughput sequencing reveals differential expression of miRNAs in intestine from sea cucumber during aestivation [miRNA-Seq]
The regulatory role of miRNA in gene expression is an emerging hot new topic in the control of hypometabolism. Sea cucumber aestivation is a complicated physiological process that includes obvious hypometabolism as evidenced by a decrease in the rates of oxygen consumption and ammonia nitrogen excre...
ORGANISM(S): Apostichopus japonicus 
2014-06-06 | E-GEOD-48867 | biostudies-arrayexpress
TranscriptomicsLarge-scale identification and comparative analysis of miRNA expression profile in the respiratory tree of the sea cucumber Apostichopus japonicus during aestivation (part 2)
The sea cucumber Apostichopus japonicus withstands high water temperatures in the summer by suppressing metabolic rate and entering a state of aestivation. We hypothesized that changes in the expression of miRNAs could provide important post-transcriptional regulation of gene expression during hypom...
ORGANISM(S): Apostichopus japonicus 
2014-10-01 | E-GEOD-52225 | biostudies-arrayexpress
TranscriptomicsMesenchymal stromal cells isolated from bronchoalveolar lavage and digest parenchymal lung tissue
Stromal support is critical to the achievement of lung homeostasis and the maintenance of an effective epithelial barrier, and yet previous studies have found a positive association between the number of mesenchymal stromal cell populations (MSCs) isolated from the alveolar space and human diseases ...
ORGANISM(S): Homo sapiens 
2016-07-04 | E-GEOD-74284 | biostudies-arrayexpress
TranscriptomicsEstrogen response uterine gene profile in Ex3αERKO
WT and Ex3aERKO females were ovariectomized and injected with saline or estradiol. Uterine tissue was collected after 2 or 24 hours. RNA was analyzed by microarray to determine if the Ex3aERKO mice would lack the residual transcritpional resposnes seen in the previous aERKO model. 3 uteri per group ...
ORGANISM(S): Mus musculus 
2010-07-22 | E-GEOD-23072 | biostudies-arrayexpress
TranscriptomicsSomatic copy number variation profiling in matched brain and extracranial metastases of melanoma
An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences between bra...
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-50495 | biostudies-arrayexpress
TranscriptomicsBRE silencing effect on gene expression profile of human umbilical cord perivascular (HUCPV) progenitor cells
Analysis of HUCPV progenitor cells following BRE silencing using BRE-siRNA. BRE (Brain and reproductive organ-expressed) protein is also known as TNFRSF1A (tumor necrosis factor receptor superfamily, member 1A) modulator and BRCC45 (BRCA-1 containing complex subunit 45). Results identify gene target...
ORGANISM(S): Homo sapiens 
2012-08-08 | E-GEOD-39948 | biostudies-arrayexpress
TranscriptomicsTranscriptional dysregulation of synaptic genes in a human iPSC model of major mental disorders
Schizophrenia and other psychiatric disorders are postulated to be developmental disorders resulting from synapse dysfunction. How susceptibility genes for major mental disorders could lead to synaptic deficits in humans is not well-understood. Here we generated induced pluripotent stem cells (iPSCs...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57821 | biostudies-arrayexpress
TranscriptomicsGrowth inhibition of ovarian tumor-initiating cells by niclosamide
The gene expression profile in treated CP70 side population spheroid cells (CP70sps cells) was analyzed to investigate the effect of niclosamide inhibition on ovarian tumor-initiating cells. CP70sps cells are isolated and characterized as one kind of ovarian tumor-initiating cells, and they show ste...
ORGANISM(S): Homo sapiens 
2012-08-05 | E-GEOD-36259 | biostudies-arrayexpress
UnknownCross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis.
Not available
S-EPMC5606989 | biostudies-literature
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