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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
TranscriptomicsMEF-mKras-WT1
K-ras is one of the most frequently mutated human oncogenes. Activation of K-ras can lead to either senescence or proliferation in primary cells. The precise mechanism governing these distinct outcomes remains unclear. Here we utilized a loss-of-function screen to assess the role of specific genes ...
ORGANISM(S): Mus musculus 
2010-03-06 | E-GEOD-15325 | biostudies-arrayexpress
TranscriptomicsExpression analysis of Streptomyces avermitilis NRRL8165 delta-aveI mutant
Investigation of whole genome gene expression level changes in Streptomyces avermitilis delta-aveI mutant, compared to the wild-type strain. The mutants analyzed in this study are further described in Chen L, Lu Y., Chen J, Zhang W, Shu D, Qin Z, Yang S, Jiang W. (2008) Characterization of a negativ...
ORGANISM(S): Streptomyces avermitilis 
2010-05-16 | E-GEOD-16892 | biostudies-arrayexpress
GenomicsDNA-seq of an ELMSeq reporter cassette to study impact of C-terminal sequence variations on protein abundance
A ELMSeq reporter cassette was created to monitor Dam levels by methylation, and introduced in the genome. The regions of 6 nt upstream and 6 nt downstream the stop codon were randomized to study their effect on gene expression. The ELMSeq reporter cassette was composed of: promoter - dam - random N...
ORGANISM(S): Mycoplasma pneumoniae 
2020-05-04 | E-MTAB-8223 | biostudies-arrayexpress
TranscriptomicsNatural Variation and Timing of Stress Responses Promote and Predict Heterosis
Hybrid plants and animals grow larger and more vigorously than the parents, a common phenomenon known as hybrid vigor or heterosis. Heterosis often correlates with the genetic distance between hybridizing parents, but the mechanism for this is largely unknown. We found that genetic distance was corr...
ORGANISM(S): Arabidopsis thaliana 
2015-05-31 | E-GEOD-51578 | biostudies-arrayexpress
GenomicsMeCP2 binds to mCH as neurons mature, influencing transcription and onset of Rett syndrome [ChIP-Seq]
The postnatal neurodevelopmental disorder Rett syndrome (RTT) is caused by mutations in the gene encoding Methyl-CpG-binding Protein 2 (MeCP2). Despite decades of research, it remains unclear how MeCP2 actually regulates transcription or why RTT features appear only 6-18 months after birth. We exami...
ORGANISM(S): Mus musculus 
2015-04-15 | E-GEOD-66868 | biostudies-arrayexpress
MetabolomicsMetabolomics Study On Bacterial Cellulose Biosynthesis In Komagataeibacter hansenii HDM1-3

To investigate the metabolic shift mechanism of Komagataeibacter hansenii(K. hansenii)HDM1-3 from the bacterial growth phase to the bacterial cellulose (BC) synthesis phase,untargeted metabolomics analysis was performed on K. hansenii HDM1-3 cultures at the early fermentation stage(18h) and ...

2025-12-29 | MTBLS13586 | MetaboLights
MetabolomicsPRODH regultes naive pluripotency by influencing mitochondrial oxidative phosphorylation (Targeted metabolomics)

Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...

2024-02-12 | MTBLS7832 | MetaboLights
MetabolomicsPRODH regultes naive pluripotency by influencing mitochondrial oxidative phosphorylation (Untargeted metabolomics)

Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...

2024-02-12 | MTBLS7840 | MetaboLights
UnknownWhole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals.
Not available
S-EPMC12418676 | biostudies-literature
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