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MetabolomicsFFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes

The function of islet macrophages is poorly understood. They promote glucose-stimulated insulin secretion (GSIS) in lean mice, however, the underlying mechanism has remained unclear. We show that activation of the free fatty acid receptor FFAR4 on islet macrophages leads to interleukin-6 (IL-6) r...

2026-08-19 | MTBLS12317 | MetaboLights
UnknownLess invasive surfactant administration versus endotracheal surfactant instillation followed by limited peak pressure ventilation in preterm infants with respiratory distress syndrome in China: study protocol for a randomized controlled trial.
Not available
S-EPMC7289227 | biostudies-literature
UnknownTobacco Product Use and Functionally Important Respiratory Symptoms Among US Adolescents/Young Adults.
Not available
S-EPMC9615440 | biostudies-literature
ProteomicsMulti-omics revealed molecular mechanisms underlying guard cell systemic acquired resistance
Systemic Acquired Resistance (SAR) as a plant immune response improves immunity of distal tissue after local exposure to a pathogen. Stomata pores on leaf surfaces are formed by guard cells that recognize bacterial pathogens via pattern recognition receptors. We found that Arabidopsis thaliana plant...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-09-09 | PXD022880 | Pride
Fatty acid Immunity Guard cell Redox Multi-omics Systemic acquired resistance 
ProteomicsThree-in-one simultaneous extraction of proteins, metabolites and lipids for multi-omics
Elucidation of complex molecular networks requires integrative analysis of molecular features and changes at different levels of information flow and regulation. Accordingly, high throughput functional genomics tools such as transcriptomics, proteomics, metabolomics and lipidomics have emerged to pr...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-08-17 | PXD023094 | Pride
Arabidopsis thaliana Proteomics Systemic acquired resistance Multi-omics Metabolomics Lipidomics 
ProteomicsIdentification of DIR1-dependant cellular responses required for systemic acquired resistance in guard cells
After localized invasion by bacterial pathogens, systemic acquired resistance (SAR) is induced in uninfected plant tissues, resulting in enhanced defense against a broad range of pathogens. Although SAR requires mobilization of signaling molecules via the plant vasculature, the specific mechanisms r...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-02-17 | PXD024991 | Pride
Proteomics Arabidopsis thaliana Guard cells Lipidomics Metabolomics 
UnknownRandomized, Open-Label Phase II Study Evaluating the Efficacy and Safety of Talimogene Laherparepvec in Combination With Ipilimumab Versus Ipilimumab Alone in Patients With Advanced, Unresectable Melanoma.
Not available
S-EPMC6075852 | biostudies-literature
TranscriptomicsComparative analysis of transcripts associated with all-stage resistance to stripe rust in wheat
Stripe rust, caused by Puccinia striiformis f. sp. tritici, is a destructive disease of wheat worldwide. Genetic resistance is the preferred method for controlling stripe rust, of which two major types are race-specific and race non-specific resistance. Race-specific resistance includes the qualitat...
ORGANISM(S): Triticum aestivum 
2010-05-19 | E-GEOD-13346 | biostudies-arrayexpress
UnknownMenu Assessment Tools Used in Residential Aged Care: A Scoping Review of Content and Quality.
Not available
S-EPMC12280851 | biostudies-literature
ProteomicsQuantitative profiling of the enzymatic activity of the protein lysine mono-methyltransferase SMYD2 using SILAC-based proteomics
The significance of non-histone lysine methylation in cell biology and human disease is an emerging area of research exploration, and small molecule inhibitors that selectively and potently target “writers” and “erasers” of methyl-lysine, such as the protein lysine mono-methyltransferase SMYD2, are ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080785 | MassIVE
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