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Nutrient cues shape adipose homeostasis; however, the mechanism by which inorganic signals engage organelle networks to drive white fat browning remains unclear. Here, we identify a nitrate-Sialin2 pathway that converts dietary nitrate into a spatially confined thermogenic program. Sialin2 localizes...
ORGANISM(S): Homo sapiens (Human) 
2026-05-20 | PXD076314 | Pride
This project aims to investigate N-linked glycosylation modifications in bone marrow cells (BMCs) of an autosomal dominant osteopetrosis type 2 (ADO2) mouse model carrying the Clcn7 (r284w) mutation. Using LC-MS/MS-based 4D Label-Free N-Glycosylation Proteomics Analysis, we identified significant al...
ORGANISM(S): Mus Musculus 
2025-02-05 | PXD060501 |
This project focuses on the global proteomic profiling of bone marrow cells (BMCs) in the ADO2 mouse model using LC-MS/MS-based 4D Label-Free Proteomics Analysis. The study aims to identify differentially expressed proteins and elucidate potential molecular mechanisms underlying osteopetrosis pathog...
ORGANISM(S): Rattus Rattus 
2025-02-05 | PXD060536 |
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