Proteomics

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LC-MS/MS-based 4D Label-Free N-Glycosylation Proteomics Analysis of Bone Marrow Cells from ADO2 Mouse

ABSTRACT: This project aims to investigate N-linked glycosylation modifications in bone marrow cells (BMCs) of an autosomal dominant osteopetrosis type 2 (ADO2) mouse model carrying the Clcn7 (r284w) mutation. Using LC-MS/MS-based 4D Label-Free N-Glycosylation Proteomics Analysis, we identified significant alterations in the N-glycosylation landscape of ADO2 BMCs compared to wild-type (WT) controls. These findings provide insights into the role of glycosylation in ADO2 pathogenesis, particularly in mononuclear phagocytes.

ORGANISM(S): Mus Musculus

SUBMITTER: Minglin Ou  

PROVIDER: PXD060501 | iProX | Wed Feb 05 00:00:00 GMT 2025

REPOSITORIES: iProX

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SUGAR-seq reveals the transcriptome and N-linked glycosylation landscape of mononuclear phagocytes at single-cell resolution in a mouse model of autosomal dominant osteopetrosis type 2.

Sha Yu Y   Huang Lingyu L   Zhang Lei L   Hou Xianliang X   Mo Chune C   Pan Cuiping C   Chen Gengshuo G   Luo Sha S   Ou Minglin M  

BMC biology 20250331 1

<h4>Background</h4>Heterozygous mutation of CLCN7 (R286W) is commonly found in patients with benign autosomal dominant osteopetrosis. However, there is no evidence from animal models to confirm that it is a disease mutation. And the characteristics of the bone marrow cell (BMC) landscape in osteopetrosis at the single-cell level are completely unknown till now.<h4>Results</h4>In this study, we generated the first autosomal dominant osteopetrosis type 2 (ADO2) mouse model with typical phenotypes  ...[more]

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