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MetabolomicsVegetable Signatures Derived from Human Urinary Metabolomic Data in Controlled Feeding Studies
Examination of changes in urinary metabolomic profiles after vegetable ingestion may lead to new methods of assessing plant food intake. To this regard, we developed a proof-of-principle methodology to identify urinary metabolomic signatures for spinach, celery, and onion. Three feeding studies were...
2019-05-30 | MTBLS683 | MetaboLights
TranscriptomicsIdentification of differentially expressed genes in LBH589-treated cells
To identify the targets of LBH589 treatment, we compared gene expression profiles in three different types of human cancer cell lines (H295R, HeLa and MCF-7her2) with and without LBH589 treatment. Affymetrix microarray analysis was performed to determine changes in gene expression that are unique t...
ORGANISM(S): Homo sapiens 
2015-03-02 | E-GEOD-36509 | biostudies-arrayexpress
TranscriptomicsExpression data from GNMT knockout mice
We report that 7 of 7 female Gnmt-/- mice developed hepatocellular carcinoma (HCC), the most common form of liver cancer, at the mean age of 16.1 months. In contrast, only one-third (2/6) of male Gnmt-/- mice had HCC, the remaining had either premature death or liver necrosis. Microarray analysis sh...
ORGANISM(S): Mus musculus 
2008-12-01 | E-GEOD-9809 | biostudies-arrayexpress
TranscriptomicsIdentification of differentially expressed genes due to LBH589 treatment in aromatase inhibitor-resistant tumors
In order to validate the utility of a novel pathway algorithm (BD-Func), we test if an LBH589 signature based data from 3 cell lines (GSE36509) in an independent experiment in vivo. Xenograft tumor treatment (see Kubo et al. 2012; PMID 23160924), microarray gene expression profiling, functional anal...
ORGANISM(S): Homo sapiens 
2014-03-10 | E-GEOD-47346 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression profiles in Aromatase Inhibitor-Resistant, Tamoxifen-Resistant and LTED breast cancer cell lines.
Resistance to endocrine therapy agents has presented a clinical obstacle in the treatment of hormone-dependent breast cancer. Our laboratory has initiated a study of microRNA regulation of signaling pathways that may result in breast cancer progression on aromatase inhibitors (AI). Microarray anal...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-17775 | biostudies-arrayexpress
UnknownHost deficiency in ephrin-A1 inhibits breast cancer metastasis.
Not available
S-EPMC7194498 | biostudies-literature
UnknownThe receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ.
Not available
S-EPMC5819349 | biostudies-literature
UnknownSelective inhibition of mTORC1 in tumor vessels increases antitumor immunity.
Not available
S-EPMC7455083 | biostudies-literature
TranscriptomicsSystematic Comparison of Mouse and Human Oral Squamous Cell Carcinoma by Using Functional Transcriptomic Analysis
This study aims to compare the global expression signature of protein coding genes between oral cancers from carcinogen-induced mice and human patients. Combinatorial treatment of 4NQO and arecoline for 8 weeks consistently induced the formation of mouse oral cancer with morphology and pathology res...
ORGANISM(S): Mus musculus 
2015-12-17 | E-GEOD-64271 | biostudies-arrayexpress
UnknownClinical Features and Multiplatform Molecular Analysis Assist in Understanding Patient Response to Anti-PD-1/PD-L1 in Renal Cell Carcinoma.
Not available
S-EPMC8004696 | biostudies-literature
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