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ProteomicsDistinct Molecular Signature of Asymptomatic COVID-19 Revealed by Lipidomic Characterization
Asymptomatic infection has become one of the biggest challenges in controlling the spread of COVID-19. However, the rapid diagnosis and pathogenesis elucidation of the disease remain critical issues. Here, we performed comprehensive lipidomic profiling of 267 serum samples from 89 asymptomatic COVID...
ORGANISM(S): Homo Sapiens 
2022-06-14 | PXD024410 |
ProteomicsIsomer-Resolved Enzyme-Centric Chemoproteomics Reveals Structure-Specific Fatty Acid S-Acylation Modification Networks
Protein lipidation is a critical post-translational modification, but the relationship between the fine structure of fatty acids (FAs) and the specificity of lipidation remains largely unexplored. Here, we developed an isomer-resolved enzyme-centered chemoproteomic strategy to elucidate the intricat...
ORGANISM(S): Homo Sapiens 
2026-02-06 | PXD074124 |
Proteomics4D-diaXLMS: Proteome-wide Four-Dimensional Data-Independent Acquisition Workflow for Cross-linking Mass Spectrometry
Cross-linking Mass Spectrometry (XL-MS) is a powerful tool for examining protein structures and interactions. Nevertheless, anal-ysis of low-abundance cross-linked peptides is often limited in data-dependent acquisition (DDA) mode due to its semistochastic nature. To address this issue, we introduce...
ORGANISM(S): Homo Sapiens Saccharomyces Cerevisiae 
2023-06-26 | PXD043282 |
ProteomicsUltra-High-Throughput Mapping of the Chemical Space of Asymmetric Catalysis Enables Accelerated Reaction Discovery
The discovery of highly enantioselective catalysts and elucidating their generality face great challenges due to the complex multidimensional chemical space of asymmetric catalysis and inefficient screening methods. Here, we develop a general strategy for ultra-high-throughput mapping the chemical s...
ORGANISM(S): Acyrthosiphon Pisum 
2023-10-18 | PXD045953 |
ProteomicsDual-Resolving of Positional and Geometric Isomerism of C=Cs via Bifunctional Visible-light-activated Photocycloaddition-Photoisomerization Reaction System
The biological functions of lipids largely depend on their chemicalspatial structures. The position and configuration of C=C bonds are two of the essential attributes that determine the structures of unsaturated lipids. However, simultaneous identification of both attributes remains challenging. Her...
ORGANISM(S): Homo Sapiens Arabidopsis Thaliana 
2022-02-19 | PXD031819 |
ProteomicsHigh-Coverage Four-Dimensional Data-Independent Acquisition Proteomics and Phosphoproteomics Enabled by Deep Learning-Driven Multi-Dimensional Prediction
Here, a workflow of 4D DIA proteomics by using the predicted multi-dimensional in silico library was established. A deep learning model Deep4D that could high-accurately predict the CCS and RT of both the unmodified and phosphorylated peptides was developed, which is the model based on self-attentio...
ORGANISM(S): Homo Sapiens Mus Musculus Saccharomyces Cerevisiae 
2023-04-19 | PXD034553 |
ProteomicsNon-targeted metabonomics analysis of follicular fluid in patients with endometriosis
Non-targeted metabonomics analysis of follicular fluid in patients with endometriosis.
ORGANISM(S): Homo Sapiens 
2022-06-22 | PXD034813 |
ProteomicsMechanistic Insight into Glioma Through Spatially Multidimensional Proteomics
Characterizing the tumor microenvironment at the molecular level is essential for understanding the mechanisms of tumorigenesis and evolution. However, the specificity of the blood proteome in localized region of the tumor and its linkages with other systems is difficult to investigate. Here, we pro...
ORGANISM(S): Homo Sapiens 
2023-07-20 | PXD043970 |
ProteomicsClickable Multi-targeting Cross-Linkers Base on SuFEx for In Vivo Cross-Linking Mass Spectrometry
Cross-linking mass spectrometry (XL-MS) is a powerful technique to study protein structures and protein–protein interactions. The coverage of amino acids determines the accuracy and depth of XL-MS analysis. In this work, we designed and synthesized a pair of novel tris-functional cross-linkers, succ...
ORGANISM(S): Homo Sapiens 
2025-04-27 | PXD063377 |
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