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TranscriptomicsExpression data from a human MLL-AF6 positive AML cell line
The MLL gene on chromosome 11 fuses to the AF6 gene on chromosome 6 in a balanced chromosomal translocation that is characetristic of certain adult and pediatric human leukemias. We established a murine leukemia model of MLL-AF6 using the retroviral MLL-AF6 contruct in a bone marrow transplantation ...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-43068 | biostudies-arrayexpress
GenomicsGenome wide mapping of histone 3 lysine 79 dimethylation in MLL-AF6 murine leukemias
We report the genome wide distribution of H3K79 dimethylation in mouse MLL-AF6 positive leukemias to assess whether this epigenetic mark drives MLL-target gene expression. Examination of H3K79 dimethylation in bone marrow cells from sacrificed terminally ill MLL-AF6 positive leukemic mice. The retr...
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-43062 | biostudies-arrayexpress
TranscriptomicsExpression data from MLL-AF6 positive leukemia cells
The MLL gene on chromosome 11 fuses to the AF6 gene on chromosome 6 in a balanced chromosomal translocation that is characetristic of certain adult and pediatric human leukemias. We established a murine leukemia model of MLL-AF6 using the retroviral MLL-AF6 contruct in a bone marrow transplantation ...
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-43067 | biostudies-arrayexpress
UnknownRole of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma.
Not available
S-EPMC4169410 | biostudies-literature
Proteomics,MultiomicsIdentification SETD1A-binding proteins by Co-IP MS
The dataset contains the gelLC MS analysis of immunoprecipitated complex from full-lenght and truncated SETD1A. The protein was ectopically expressed and the binders immunoprecipitated in cell transduced with the empty vector were analyzed as control.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-01 | MSV000080012 | MassIVE
TranscriptomicsDOT1L Inhibits SIRT1 and SUV39H1-Mediated H3K9 Modification to Maintain Gene Expression (array)
Methylation of histone 3 on lysine 79 (H3K79) is broadly associated with active gene expression in eukaryotes, and the H3K79 methyltransferase DOT1L is indispensable for specific leukemia subtypes like those with MLL-translocations. We found that suppression of the histone deacetylase SIRT1 rescued ...
ORGANISM(S): Mus musculus 
2015-03-30 | E-GEOD-61013 | biostudies-arrayexpress
GenomicsDOT1L Inhibits SIRT1 and SUV39H1-Mediated H3K9 Modification to Maintain Gene Expression (ChIPseq)
Methylation of histone 3 on lysine 79 (H3K79) is broadly associated with active gene expression in eukaryotes, and the H3K79 methyltransferase DOT1L is indispensable for specific leukemia subtypes like those with MLL-translocations. We found that suppression of the histone deacetylase SIRT1 rescued ...
ORGANISM(S): Mus musculus 
2015-03-30 | E-GEOD-61021 | biostudies-arrayexpress
GenomicsDOT1L Inhibits SIRT1 and SUV39H1-Mediated H3K9 Modification to Maintain Gene Expression [ChIP-seq 2]
Methylation of histone 3 on lysine 79 (H3K79) is broadly associated with active gene expression in eukaryotes, and the H3K79 methyltransferase DOT1L is indispensable for specific leukemia subtypes like those with MLL-translocations. We found that suppression of the histone deacetylase SIRT1 rescued ...
ORGANISM(S): Homo sapiens 
2015-03-30 | E-GEOD-62100 | biostudies-arrayexpress
UnknownA polygenic resilience score moderates the genetic risk for schizophrenia.
Not available
S-EPMC7058518 | biostudies-literature
UnknownLymphocyte reconstitution after DMF discontinuation in clinical trial and real-world patients with MS.
Not available
S-EPMC7837440 | biostudies-literature
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