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UnknownAn open-label study on the safety and immunogenicity of a PD-1-enhanced DNA vaccine used as a T cell booster for COVID-19.
Not available
S-EPMC12143208 | biostudies-literature
TranscriptomicsNFAT-dependent IL-2 and IL-23 produced by DC are key regulators of pathogenic (TH17-mediated lung inflammation)
Calcineurin/NFAT/IL-2 signaling pathway is activated in dendritic cells (DC) upon encounter of β glucan, the main component of the fungal cell wall, raising the question about the role of NFAT-regulated genes in DC biology in vivo. To directly assess the function of IL-2 secreted by DC, we analyzed...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-58590 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of B-cells stimulated by different compounds (CIDR GST anti Ig)
Transcription profiling of B-cells stimulated by different compunds (CIDR; GST; anti Ig)
ORGANISM(S): Homo sapiens 
2005-06-30 | E-MEXP-316 | biostudies-arrayexpress
UnknownPhase II Study of BGJ398 in Patients With FGFR-Altered Advanced Cholangiocarcinoma.
Not available
S-EPMC6075847 | biostudies-literature
TranscriptomicsRole of Humoral Immunity against Hepatitis B Virus Core Antigen in the Pathogenesis of Acute Liver Failure
To investigate the role of viral and host factors in acute liver failure, we analyzed serum and multiple liver specimens obtained at the time of liver transplantation from four well-characterized patients. We carried out an integrated clinicopathological analysis, gene and microRNA expression profil...
ORGANISM(S): Homo sapiens 
2018-10-29 | E-GEOD-96851 | biostudies-arrayexpress
TranscriptomicsIllumina sequencing of small RNAs from C. elegans embryos
Caenorhabditis elegans is one of the most prominent model systems to study embryogenesis. However, it has been impractical to collect large amounts of precisely staged embryos. Thus, early C. elegans embryogenesis has not been amenable to most modern high-throughput genomics or biochemistry assays. ...
ORGANISM(S): Caenorhabditis elegans 
2009-09-06 | E-GEOD-17153 | biostudies-arrayexpress
TranscriptomicsA transcriptome atlas of rice cell types uncovers cellular, functional and developmental hierarchies
Whole-genome transcriptional profiles of rice cell types, isolated by laser-capture microdissection. The first comprehensive multi-organ cell type transcriptome atlas from a plant, with 40 distinct cell types from several developmental stages of seeds, shoots and roots, reveals cell-specific promote...
ORGANISM(S): Oryza sativa 
2010-05-19 | E-GEOD-13161 | biostudies-arrayexpress
TranscriptomicsIdentification of transcripts whose abundance changes in response to acute switches in DSX isoform
RNAseq of dissected adult fat body after DSX isoform is switched using temperature inducible alleles or constructs. Biological duplicates were sequenced for each genotype at each condition.
ORGANISM(S): Drosophila melanogaster 
2014-10-30 | E-GEOD-55848 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestines
Rb and E2F are thought to play antagonistic roles in celll proliferation. However, this model is based mostly from in vitro cell culture systems. We used small intestines to test this model in vivo. We found that deletion of E2f1-3 in the small intestine of mice suppressed the ectopic expression o...
ORGANISM(S): Mus musculus 
2010-01-19 | E-GEOD-16454 | biostudies-arrayexpress
GenomicsIdentifying targets of DSX with DamID-seq
We have adapted the DamID protocol for use with high throughput sequencing. We have used DamID to identify the positions within the Drosophila genome where the transcription factor DSX is bound. We sequenced DpnI-digested genomic DNA from fly tissues containing UAS-Dam (control) or UAS-Dam-DsxF or ...
ORGANISM(S): Drosophila melanogaster 
2014-10-30 | E-GEOD-27269 | biostudies-arrayexpress
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