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TranscriptomicsTranscription profiling of mouse muscle mutant to reveals skeletal muscle growth and fiber composition in mice are regulated through the transcription factors STAT5a/b
In skeletal muscle, STAT5a/b transcription factors are critical for normal postnatal growth, whole-animal glucose homeostasis, and local IGF-1 production. These observations have led us to hypothesize that STAT5a/b are critical for maintenance of normal muscle mass and function. To investigate thi...
ORGANISM(S): Mus musculus 
2009-09-05 | E-GEOD-14710 | biostudies-arrayexpress
TranscriptomicsMicroarray Experiments for mice lacking or with the Stat5a and 5b genes in blood cells that were treated w/o CMP
GM-CSF controls the development of granulocytes but little is known about the contribution of the downstream mediating transcription factor STAT5A/B. To elucidate this pathway, we generated mice lacking the Stat5a and 5b genes in blood cells. Peripheral neutrophils were decreased and administratio...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-14698 | biostudies-arrayexpress
MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
TranscriptomicsTranscription profiling of human cell cancer line treated with bortezomib or Eeyarestatin I (EerI) reveals ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3 only protein NOXA in cancer cells
The ubiquitin-proteasome system (UPS) has recently emerged as a major target for drug development in cancer therapy. The proteasome inhibitor bortezomib has clinical activity in multiple myeloma and mantle cell lymphoma. Here we report that Eeyarestatin I (EerI), a chemical inhibitor that blocks ER-...
ORGANISM(S): Homo sapiens 
2009-02-28 | E-GEOD-14003 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild type and Stat5a or 5b knock-out blood cells treated with GM-CSF to induce granulopoiesis
GM-CSF controls the development of granulocytes but little is known about the contribution of the downstream mediating transcription factor STAT5A/B. To elucidate this pathway, we generated mice lacking the Stat5a and 5b genes in blood cells. Peripheral neutrophils were decreased and administratio...
ORGANISM(S): Mus musculus 
2009-10-10 | E-GEOD-14672 | biostudies-arrayexpress
TranscriptomicsThe transcription factors STAT5a/b negatively regulate cell proliferation through the activation of cdkn2b and cdkn1a expression
Although the cytokine-inducible transcription factors STAT5a/b promote proliferation of a wide range of cell types, there are cell- and context specific cases in which loss of STAT5a/b results in enhanced cell proliferation. Here we report that loss of STAT5a/b from mouse embryonic fibroblasts (MEFs...
ORGANISM(S): Mus musculus 
2010-11-15 | E-GEOD-21861 | biostudies-arrayexpress
TranscriptomicsIndoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand, mediates progressive glomerular disease by damaging podocytes
Indoxyl sulfate (IS) is a uremic toxin and ligand of the aryl-hydrocarbon receptor (Ahr), a transcriptional regulator. Elevated serum IS may contribute to the progression of kidney disease. Therefore, we assessed mouse podocyte damage mediated by IS. Ahr was predominantly localized to the podocyte n...
ORGANISM(S): Homo sapiens 
2014-10-14 | E-GEOD-51834 | biostudies-arrayexpress
TranscriptomicsBroad shifts in gene expression during early postnatal life are associated with shifts in histone methylation patterns
During early postnatal life, extensive changes in gene expression occur concomitantly in multiple major organs, indicating the existence of a common core developmental genetic program. This program includes hundreds of growth-promoting genes that are downregulated with age in liver, kidney, lung, an...
ORGANISM(S): Mus musculus 
2014-08-04 | E-GEOD-49785 | biostudies-arrayexpress
TranscriptomicsTemporal changes of gene expression in rat kidney and lung, and the effect of prior growth inhibition on these changes
Temporal changes of gene expression from 1-wk- to 5-wk-old rat in kidney and lung, and the effect of prior growth inhibition on these genetic changes. In mammals, body growth is rapid in early life but decelerates with age. Somatic growth deceleration is caused by a gradual decline in cell prolifera...
ORGANISM(S): Rattus norvegicus 
2010-09-16 | E-GEOD-16792 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Saccharomyces cerevisiae mutant delta-spe3 delta-fms1 after spermidine treatment
The naturally occurring polyamines putrescine, spermidine or spermine are ubiquitous in all cells. Although polyamines have prominent regulatory roles in cell division and growth, precise molecular and cellular functions are not well established in vivo. In this work we have performed a microarray e...
ORGANISM(S): Saccharomyces cerevisiae 
2009-09-05 | E-GEOD-15269 | biostudies-arrayexpress
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