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ProteomicsEnrichment of NICD4 interacting proteins by three different methods.
There are several methods to bring down the bait and interactors from the cell lysates, each with its own advantages and disadvantages. Recently, the most commonly used method is one step AP, TAP and proximity-labeling. In order to analyze the Strengths and weaknesses of the three methods, fusion pr...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031772 | Pride
Sfb-tap Nicd4 Flag tag ap Turboid. 
ProteomicsGamma secretase complex and DOCK2 affinity interactome.
γ-secretase is a transmembrane protease complex responsible for processing multiple type I transmembrane proteins, including the amyloid precursor protein and NOTCH. Despite various γ-secretase inhibitors and modulators developed in the past decades to target Notch-dependent cancers, their clinical ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-31 | PXD057036 | Pride
Nicastrin Dock2 Leukemia Gamma secretase Notch 
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