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MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
UnknownA non-canonical role of the inner kinetochore in regulating sister-chromatid cohesion at centromeres
Not available
S-SCDT-10_1038-S44318-024-00104-6 | biostudies-other
MetabolomicsGNPS - Integrative proteogenomic characterization of colorectal cancer cell lines and primary tumors
Solid tumors are complex organs comprising neoplastic cells and stroma, yet cancer cell lines remain widely used to study tumor biology, biomarkers and experimental therapy. Here, we performed a fully integrative analysis of global proteomic data comparing human colorectal cancer (CRC) cell lines to...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-12-01 | MSV000080374 | GNPS
MetabolomicsCancer-cell-secreted exosomal miR-105 promotes tumour growth through the Myc-dependent metabolic reprogramming of stromal cells
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and to buffer the negative effects of environmental changes. Extracellular miRNAs have been recently implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-canc...
2018-07-10 | MTBLS626 | MetaboLights
ProteomicsProteomic Profiling and Biomarker Discovery for Predicting Response to PD-1 Inhibitor Immunotherapy in Gastric Cancer Patients
Revolutionizing cancer treatment, immune checkpoint inhibitors (ICIs) have nonetheless encountered a challenge: a substantial portion of gastric cancer (GC) patients don’t respond to this therapy. This pressing issue necessitates a deeper understanding of the resistance mechanisms against ICIs and t...
ORGANISM(S): Homo Sapiens 
2024-02-29 | PXD050228 |
Proteomics,MultiomicsIntegrative proteogenomic characterization of colorectal cancer cell lines and primary tumors
Solid tumors are complex organs comprising neoplastic cells and stroma, yet cancer cell lines remain widely used to study tumor biology, biomarkers and experimental therapy. Here, we performed a fully integrative analysis of global proteomic data comparing human colorectal cancer (CRC) cell lines to...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-12-01 | MSV000080374 | MassIVE
ProteomicsPhysiological and proteomic analysis responsive mechanisms for salt stress in oat
Oat is considered as a moderately salt-tolerant crop that can be used to improve saline and alkaline soils. Previous studies have focused on short-term salt stress exposure, and the molecular mechanisms of salt tolerance in oat have not yet been elucidated. In this study, the salt-tolerant oat varie...
ORGANISM(S): Oryza Sativa 
2022-05-30 | PXD034203 |
ProteomicsMulti-omics reveal the metabolic patterns in mouse cumulus cells during oocyte maturation
Bi-directional communication between cumulus cells and the surrounded oocytes is important for the development and functions of both compartments. However, the metabolic framework in cumulus cells has not been systematically described. In the present study, cumulus cells from cumulus-oocyte complex...
ORGANISM(S): Mus Musculus 
2023-03-10 | PXD040796 |
ProteomicsProteome profiling of N2a pretreated with ALDH2
Aldehyde dehydrogenase 2 family member (ALDH2) is a key mitochondrial dehydrogenase that functions in the detoxification of acetaldehyde, and endogenous 4-hydroxy-2-nonenal (4-HNE) and malondialdehyde generated by polyunsaturated fatty acid peroxidation. In this study, we found that altered ALDH2 en...
ORGANISM(S): Mus Musculus 
2023-11-24 | PXD047209 |
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