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UnknownGDF11 does not rescue aging-related pathological hypertrophy.
Not available
S-EPMC4636963 | biostudies-literature
TranscriptomicsA dysregulated Acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity
Acetylation of transcriptional regulators is normally dynamically regulated by nutrient status but is often persistently elevated in nutrient-excessive obesity conditions. We investigated the functional consequences of such aberrantly elevated acetylation of the nuclear receptor FXR as a model. Prot...
ORGANISM(S): Mus musculus 
2014-10-17 | E-GEOD-62414 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis of experimental autoimmune encephalomyelitis mice implicates SUMOylation in multiple sclerosis
In this study, we performed quantitative proteomics utilizing a data-independent acquisition (DIA) strategy to investigate the proteome alteration in the brain and spinal cord tissues from mice with experimental autoimmune encephalomyelitis (EAE), a widely-used model for MS.
ORGANISM(S): Mus Musculus 
2024-03-20 | PXD050789 |
MetabolomicsAltered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity

Irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders characterized by chronic and/or recurrent symptoms of abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; however, contradictory results exist, and IBS-specific microbi...

2021-12-01 | MTBLS2774 | MetaboLights
UnknownUltrabright ratiometric Raman-guided epilepsy surgery by intraoperatively visualizing proinflammatory microglia.
Not available
S-EPMC12208331 | biostudies-literature
ProteomicsInvestigating the off-target effects of Pro-BA using label-free and TMTpro quantitative proteomics
Nevertheless, in-depth characterization of the proteome could reveal unknown off-targets of Pro-BA. To address this issue, we repeated the same experiment but extended MS analysis time to 2 hours in this revision, which will be elaborated in the next point. Nonetheless, the computed p-value of ALK p...
ORGANISM(S): Homo Sapiens 
2025-03-25 | PXD062245 |
ProteomicsMultiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression
Our study provides an enabling technology and rich data resources to expand the understanding of transmembrane proteome organization and dynamics in the brain as well as accelerate the discovery of potential therapeutic targets for depression treatment.
ORGANISM(S): Mus Musculus 
2021-07-26 | PXD027559 |
ProteomicsSubcommissural organ (SCO) contributes to brain development via SCO-secreted peptides
To explore the role of SCO and its functional mechanism, we measure the SCO-derived peptide in CSF from C57B/6 mice and SCO-ablated mice.
ORGANISM(S): Mus Musculus 
2025-02-04 | PXD040641 |
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