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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
MetabolomicsFFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes

The function of islet macrophages is poorly understood. They promote glucose-stimulated insulin secretion (GSIS) in lean mice, however, the underlying mechanism has remained unclear. We show that activation of the free fatty acid receptor FFAR4 on islet macrophages leads to interleukin-6 (IL-6) r...

2026-08-19 | MTBLS12317 | MetaboLights
UnknownIdentification of plasma protein markers common to patients with malignant tumour and Abnormal Savda in Uighur medicine: a prospective clinical study.
Not available
S-EPMC4321703 | biostudies-literature
ProteomicsCell membrane remodeling mediates polymyxin B resistance in Klebsiella pneumoniae: an integrated proteomics and metabolomics study
In this study, resistance of Klebsiella pneumoniae (K. pneumoniae) to PB was induced by passaging in serial concentrations of PB. This study employed TMT-labeled quantitative proteomics and LC-MS/MS metabolomics analysis to investigate the key biological processes associated with PB resistance in K....
ORGANISM(S): Klebsiella pneumoniae LCT-KP289 
2022-01-24 | PXD030940 | Pride
Polymyxin b resistance Proteomics Metabolomics Klebsiella pneumoniae Membrane remodeling 
UnknownMaternal circulating exosomal miR-185-5p levels as a predictive biomarker in patients with recurrent pregnancy loss.
Not available
S-EPMC10033820 | biostudies-literature
UnknownDesign of a multi-epitope vaccine candidate against Brucella melitensis.
Not available
S-EPMC9202987 | biostudies-literature
UnknownCandidate target genes in sepsis diagnosis and therapy: identifying hub genes with a spotlight on KLRB1.
Not available
S-EPMC11938612 | biostudies-literature
UnknownA Machine Learning-Based Prediction Model for Acute Kidney Injury in Patients With Community-Acquired Pneumonia: Multicenter Validation Study.
Not available
S-EPMC11695953 | biostudies-literature
ProteomicsSsrp1 co-immunoprecipitation and mass spectrometry
Endogenous retroviruses (ERVs) were usually silenced by various histone modifications on histone H3 variants and respective histone chaperones in embryonic stem cells (ESCs). However, it is still unknown whether chaperones of other histones could repress ERVs. Here, we show that H2A/H2B histone chap...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-24 | PXD017351 | Pride
Ssrp1 Co-immunoprecipitation Mass spectrometry Esc 
UnknownShibi Tea (Adinandra nitida) and Camellianin A Alleviate CCl4-Induced Liver Injury in C57BL-6J Mice by Attenuation of Oxidative Stress, Inflammation, and Apoptosis.
Not available
S-EPMC9332116 | biostudies-literature
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