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MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
MetabolomicsGut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy
Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through the production of gut-derived metabolites. However, the specific metabolites and their pathophysiological contribution to cardiac hypertrophy or heart failure progression ...
2021-12-08 | MTBLS3174 | MetaboLights
UnknownCausal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping.
Not available
S-EPMC7371536 | biostudies-literature
UnknownBcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis.
Not available
S-EPMC5261001 | biostudies-literature
UnknownThe histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ<sup>+</sup>CD8αα<sup>+</sup> intestinal intraepithelial lymphocytes.
Not available
S-EPMC9287323 | biostudies-literature
UnknownIron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses.
Not available
S-EPMC6610088 | biostudies-literature
UnknownAcetylation of TIR domains in the TLR4-Mal-MyD88 complex regulates immune responses in sepsis
Not available
S-SCDT-10_1038-S44318-024-00237-8 | biostudies-other
ProteomicsInhibition of a novel CLK1-THRAP3-PPARγ axis improves insulin sensitivity
CLK1 plays a critical role in controlling energy expenditure through the CLK1-Thrap3-PPARγ axis.
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-08-16 | PXD027958 |
Unknown6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Not available
S-EPMC4628560 | biostudies-literature
UnknownType 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2.
Not available
S-EPMC8554487 | biostudies-literature
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