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ProteomicsExogenous creatine supplementation promotes tumor metastasis via megakaryocyte creatine kinase B-STAT5B signaling
Creatine supplementation is widely used in sports and increasingly popular among exercising individuals. Although the physiological role of creatine has been extensively studied, the creatine biology in pathological status remains poorly understood. Here we report that exogenous creatine supplementa...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-27 | PXD065649 | Pride
UnknownThe relationship between longer leukocyte telomeres and dNCR in non-cardiac surgery patients: a retrospective analysis.
Not available
S-EPMC10463441 | biostudies-literature
MetabolomicsMirabegron displays anticancer effects by globally browning adipose tissues

Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion and metastasis. However, the impact of global adipose metabolism on tumor growth and the drug development by targeting adipose metabolism remain larg...

2023-11-08 | MTBLS8682 | MetaboLights
UnknownLoss of histone methyltransferase Smyd3 triggers WAT browning and adaptive thermogenesis via enhancing PPARγ expression in a H4K20me3-dependent manner.
Not available
S-EPMC12486502 | biostudies-literature
ProteomicsDimethyl phthalate changed pseudomonas fluorescens proteomics
Effect of dimethyl phthalate on proteomics of pseudomonas fluorescens
ORGANISM(S): Escherichia Coli 
2022-01-02 | PXD030689 |
ProteomicsSuccinyl-CoA synthetase deficiency in mouse forebrain results in hyper-succinylation with perturbed neuronal transcriptional regulation and metabolism
Lysine-succinylation is a subtype of protein acylation associated with metabolic regulation of succinyl-CoA in the TCA cycle. Deficiency of succinyl-CoA synthetase (SCS), the TCA-cycle enzyme catalyzing the reversible conversion of succinyl-CoA to succinate, leads to mitochondrial encephalomyopathy ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-06-21 | MSV000089697 | MassIVE
MetabolomicsBrown-fat-mediated tumour suppression by cold-altered global metabolism

Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues. Most cancers use glycolysis to harness energy for their infinite growth, invasion and metastasis. Activation of thermogenic metabolism in brown adipose tissue (BAT) by cold an...

2022-08-12 | MTBLS4856 | MetaboLights
ProteomicsSynthetic lethal combinations targeting PLK1-CBX8-GPX4 axis with BRAF and EGFR inhibition in BRAF V600E colorectal cancer
Metastatic BRAFV600E colorectal cancer (CRC) confers poor prognosis and run into a bottleneck in the current treatment strategies. To identify regulatory pathways independent of the MAPK pathway in BRAFV600E CRC, we performed CRISPR-Cas9 screening, and and find targeting glutathione peroxidase 4 (GP...
ORGANISM(S): Homo Sapiens 
2024-11-25 | PXD058213 |
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