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ProteomicsOne Brucella proteins solution sample, complete protein and 5 modifications Label-free omics research (No duplication,F8097WB remaining protein) analysis report.
Considering the role of PTMs(2-hydroxyisobutyrylation, succinylation, crotonylation, acetylation, and malonylation) in various biological processes of Brucella virulence and survival, we propose that the virulence of Brucella is associated with the PTMs of proteins. Taken together, this study provid...
ORGANISM(S): Brucella abortus (strain 2308) 
2022-03-04 | PXD030621 | Pride
Brucella 2308 lc-msms 
ProteomicsThe Ubiquitin-modified Proteome of SARS-CoV-2-infected Host Cells Reveals Insights into Virus-Host Interaction and Pathogenesis
The outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed a serious threat to global public health. The mechanism of pathogenesis and host immune response to SARS-CoV-2 infection are largely unknown. In the present...
ORGANISM(S): SARS coronavirus GD322 
2021-03-08 | PXD021097 | Pride
Coronavirus disease 2019  severe acute respiratory syndrome coronavirus 2  lc-ms  ubiquitome 
ProteomicsGlobal Lysine Crotonylation Alterations of Host Cell Proteins Caused by Brucella GNAT Containing Effector BspF
In Brucella spp., the type IV secretion system (T4SS) is essential for bacterial intracellular survival and inhibition of the host innate immune response. The Brucella T4SS secretes 15 different effectors to escape host immunity and promote intracellular replication. Among them, BspF has a GNAT-fami...
ORGANISM(S): Brucella sp. 
2021-09-09 | PXD021423 | Pride
Brucella  t4ss  effector  bspf  lysine crotonylation  crotonyltransferase 
ProteomicsComparative Proteomics between Brucella abortus 2308 and Genetically Marked Vaccine A19ΔvirB12 Reveal Attenuation Mechanism and Supplementary Differential Diagnosis Antigens
Brucella abortus is an important zoonotic pathogen that causes severe economic loss to husbandry and poses a threat to human health. The B. abortus A19 live vaccine has been extensively used to prevent bovine brucellosis in China. However, A19 has the limitation of diagnosis interference and residua...
ORGANISM(S): Brucella abortus (strain 2308) 
2021-09-09 | PXD022031 | Pride
B. abortus  a19δvirb12  proteomics  differential diagnosis  attenuation mechanism 
ProteomicsProteomic Analysis of Stationary Growth Stage and Nutritional Deficiency Adaptation Reveals Brucella Abortus Virulence Mechanisms
Brucellosis, an important bacterial zoonosis caused by Brucella species, has drawn increased attention around the world. As an intracellular pathogen, the ability of Brucella to deal with stress within the host cell is closely related to its virulence. The survival pressure on Brucella within a phag...
ORGANISM(S): Brucella abortus str. 2308 A 
2021-09-09 | PXD020869 | Pride
B. abortus  proteomics  logarithmic phase  stationary phase  nutritional stress 
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