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ProteomicsGPI-Anchored Ligand-BioID2-Tagging System Identifies proteins Mediating Zika Virus Entry
Identification of host factors facilitating pathogen entry is critical for preventing infectious diseases. Here, we report a tagging system consisting of a viral receptor-binding protein (RBP) linked to BioID2, which is expressed on the cell surface via a GPI anchor. Using VSV or Zika virus (ZIKV) R...
ORGANISM(S): Homo Sapiens 
2022-10-12 | PXD037307 |
MetabolomicsMicrobiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts

The perturbations of the gut microbiota and metabolites are closely associated with the progression of inflammatory bowel disease (IBD). However, inconsistent findings across studies impede a comprehensive understanding of their roles in IBD and their potential as reliable diagnostic biomarkers. ...

2026-01-28 | MTBLS8713 | MetaboLights
ProteomicsSerum-based proteomics reveals lipid metabolic and immunoregulatory 、dysregulation in cervical artery dissection with stroke
Cervical artery dissection (CAD) is an important causal factor for stroke in young and middle-aged individuals and presents a great burden to the individual stroke victim. However, the pathophysiological mechanisms underlying CAD remain unknown. Here, an isobaric tagging for relative and absolute qu...
ORGANISM(S): Homo Sapiens 
2020-01-30 | PXD017340 |
UnknownMEF2A-mediated lncRNA HCP5 Inhibits Gastric Cancer Progression via MiR-106b-5p/p21 Axis.
Background: Long non-coding RNAs (lncRNAs) are deemed to be relevant to the tumorigenesis and development of a variety of tumors, containing gastric cancer (GC). The purpose of our investigations is to explore the character of HCP5 in GC. Methods: HCP5 expression was detected by quanti...
S-EPMC7893594 | biostudies-literature
UnknownHypoxic Tumor-Derived Exosomal Long Noncoding RNA UCA1 Promotes Angiogenesis via miR-96-5p/AMOTL2 in Pancreatic Cancer.
The hypoxic microenvironment, an important feature of solid tumors, promotes tumor cells to release exosomes and enhances tumor angiogenesis. However, the detailed functions of hypoxic exosomes and the mechanisms underlying their effects in pancreatic cancer (PC) remain mysterious. Here, we observed...
S-EPMC7498711 | biostudies-literature
UnknownFBXO5-mediated RNF183 degradation prevents endoplasmic reticulum stress-induced apoptosis and promotes colon cancer progression.
Endoplasmic reticulum (ER) stress induces the unfolded protein response (UPR), and prolonged ER stress leads to cell apoptosis. Despite increasing research in this area, the underlying molecular mechanisms remain unclear. Here, we discover that ER stress upregulates the UPR signaling pathway while d...
S-EPMC10784456 | biostudies-literature
ProteomicsDependency of NELF-E-KAT2B epigenetic axis in breast cancer carcinogenesis
Cancer cells undergo transcriptional reprogramming to drive tumor progression and metastasis. Here, we identified the transcriptional complex, NELF (Negative elongation factor), as an important regulator of this process. Using cancer cell lines and patient-derived tumor organoids, we demonstrated th...
ORGANISM(S): Homo Sapiens (human) 
2023-01-28 | PXD031304 | JPOST Repository
Proteomicsc-JUN interacte with NuRD complex to regulate chromatin remodeling
detect c-JUN interaction proteins in humanembryonic stem cells
ORGANISM(S): Homo Sapiens 
2023-12-28 | PXD048153 |
ProteomicsLithocholic acid targets TULP3-Sirtuins to deacetylate v-ATPase and activate AMPK
Lithocholic acid (LCA), accumulated in mammals during calorie restriction (CR), can activate AMP-activated protein kinase (AMPK) and slow down ageing1. However, how LCA is signalled to activate AMPK and elicit the biological effects is unclear. Here, we show that LCA can enhance the activity of sirt...
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD056134 |
ProteomicsProteomics dataset of COVID-19 and control patients
Proteomics dataset of COVID-19 and control patients
ORGANISM(S): Homo Sapiens 
PXD029023 |
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