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UnknownMolecular profiling of Chinese systemic anaplastic large cell lymphoma patients: novel evidence of genetic heterogeneity.

Background

Anaplastic large cell lymphoma (ALCL) is a rare non-Hodgkin lymphoma. A comprehensive understanding of the genetic and clinical heterogeneity of ALCL may help to improve the clinical management of patients with ALCL. However, due to the rarity of the disease, the genetic heterogen...
S-EPMC7867950 | biostudies-literature
UnknownFunctional classification of prostate cancer‑associated miRNAs through CRISPR/Cas9‑mediated gene knockout.
The aim of the present study was to use the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR‑associated (Cas) 9‑mediated gene knockout technology for the rapid classification of the differential function of micro (mi)RNAs screened using miRNA expression profiling by micr...
S-EPMC7533463 | biostudies-literature
UnknownSafety and immunogenicity of aerosolised Ad5-nCoV, intramuscular Ad5-nCoV, or inactivated COVID-19 vaccine CoronaVac given as the second booster following three doses of CoronaVac: a multicentre, open-label, phase 4, randomised trial.

Background

Aerosolised Ad5-nCoV is the first approved mucosal respiratory COVID-19 vaccine to be used as a booster after the primary immunisation with COVID-19 vaccines. This study aimed to evaluate the safety and immunogenicity of aerosolised Ad5-nCoV, intramuscular Ad5-nCoV, or inactivated...
S-EPMC9991083 | biostudies-literature
UnknownLong-lived topological time-crystalline order on a quantum processor.
Topologically ordered phases of matter elude Landau's symmetry-breaking theory, featuring a variety of intriguing properties such as long-range entanglement and intrinsic robustness against local perturbations. Their extension to periodically driven systems gives rise to exotic new phenomena that ar...
S-EPMC11487055 | biostudies-literature
UnknownTopological prethermal strong zero modes on superconducting processors.
Symmetry-protected topological phases1-4 cannot be described by any local order parameter and are beyond the conventional symmetry-breaking model5. They are characterized by topological boundary modes that remain stable under symmetry respecting perturbations1-4,6-8....
S-EPMC12443636 | biostudies-literature
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
UnknownGlobal, regional, and national burden of suicide, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.

Background

Deaths from suicide are a tragic yet preventable cause of mortality. Quantifying the burden of suicide to understand its geographical distribution, temporal trends, and variation by age and sex is an essential step in suicide prevention. We aimed to present a comprehensive set of ...
S-EPMC11876099 | biostudies-literature
UnknownManagement of Coronary Disease in Patients with Advanced Kidney Disease.

Background

Clinical trials that have assessed the effect of revascularization in patients with stable coronary disease have routinely excluded those with advanced chronic kidney disease.

Methods

We randomly assigned 777 patients with advanced kidney disease and moderate or severe isch...
S-EPMC7274537 | biostudies-literature
UnknownHealth Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease.

Background

In the ISCHEMIA-CKD trial, the primary analysis showed no significant difference in the risk of death or myocardial infarction with initial angiography and revascularization plus guideline-based medical therapy (invasive strategy) as compared with guideline-based medical therapy a...
S-EPMC7255621 | biostudies-literature
UnknownGlobal incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
Not available
S-EPMC11122111 | biostudies-literature
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