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Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
UnknownORCA-SPY enables killer whale sound source simulation, detection, classification and localization using an integrated deep learning-based segmentation.
Not available
S-EPMC10333356 | biostudies-literature
ProteomicsEfficient sugar utilization and transition from oxidative to substrate-level phosphorylation in high starch storage roots of African cassava genotypes
Cassava’s storage roots represent one of the most important sources of nutritional carbohydrates worldwide. Particularly, smallholder farmers in Sub-Saharan Africa depend on this crop plant, where resilient and yield-improved varieties are of vital importance to support steadily increasing populatio...
ORGANISM(S): Manihot esculenta (Cassava) (Jatropha manihot) 
2023-06-21 | PXD038813 | Pride
Cassava 
TranscriptomicsThe role of Ninjurin-1 deficiency in Jak2V617F clonal hematopoiesis mediated atherosclerosis plaque progression
Clonal haematopoiesis of indeterminate potential (CHIP) involves age-related acquisition and expansion of genes frequently mutated in haematologic malignancies (e.g. DNMT3A, TET2, or JAK2).  JAK2 heightens cardiovascular disease (CVD) risk. The mechanism, although incompletely understood, involves p...
ORGANISM(S): Mus musculus 
2025-12-22 | E-MTAB-16375 | biostudies-arrayexpress
TranscriptomicsLow Dose PDT - Murine Tumors
Tumors were induced in C57BL/6 mice by subcutaneous injection of murine prostate carcinoma cell line TRAMP-C2. Tumor-bearing mice were narcotized, injected with photosensitizer 5-aminolaevulinic acid (5-ALA), shaven at their back, and 3-4 h later the whole tumor area was irradiated perpendicular (un...
ORGANISM(S): Mus musculus 
2011-06-25 | E-MEXP-3017 | biostudies-arrayexpress
TranscriptomicsLow dose PDT - Murine Cells
Murine prostate carcinoma cell lines TRAMP-C1 and TRAMP-C2 were grown for 16 h at 37M-0C with photosensitizer 5-aminolaevulinic acid (5-ALA; 50 M-5g/ml). Then, the cells were sublethally irradiated with laser light (635 nm) at room temperature (using RPMI1640 without phenol red as medium). After ph...
ORGANISM(S): Mus musculus 
2011-06-25 | E-MEXP-3016 | biostudies-arrayexpress
TranscriptomicsLow Dose PDT - Human Cells
Human tumour cell lines PC3, DU145, U87 and U373 (prostate carcinoma and glioblastoma) were treated with photosensitizers 5-aminolaevulinic acid (5-ALA) or photofrin. Then, the cells were irradiated sublethally with 635 nm laser light.
After photodynamic therapy, the cells were grown at 37°C for ...
ORGANISM(S): Homo sapiens 
2011-06-26 | E-MEXP-3020 | biostudies-arrayexpress
TranscriptomicsDelineation of AR oncogenic functions in hepatocellular carcinoma
The goal of this study was to delineate the important AR direct target genes that mediate the oncogenic properties of AR in HCC. The AR direct target genes in two HCC cell lines were identified by chromatin immunoprecipitation microarray (ChIP-chip) analysis and later confirmed by independent ChIP-P...
ORGANISM(S): Homo sapiens 
2011-08-07 | E-GEOD-25884 | biostudies-arrayexpress
UnknownA New Drug Combinatory Effect Prediction Algorithm on the Cancer Cell Based on Gene Expression and Dose-Response Curve.
Not available
S-EPMC4360667 | biostudies-literature
TranscriptomicsCalibration of a custom designed microarray
We designed a custom expression 8x15 k microarray for Cottus fishes based on transcriptome sequencing. It is a known fact, that oligonucleotide probes differ in the binding behavior towards their target sequences. Therefore, we performed a calibration of our microarray where we assessed the binding ...
ORGANISM(S): Cottus 
2012-03-26 | E-GEOD-36800 | biostudies-arrayexpress
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