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ProteomicsThe role and mechanism of TRPV1 SUMOylation in inhibiting the proliferation and migration of gastric cancer cells
In this work, we elucidate a novel mechanism wherein TRPV1 SUMOylation promotes its membrane expression and activates the TRPV1-Ca2+-AMPK signaling pathway, thereby inhibiting GC cell proliferation and migration. These findings enhance our understanding of the molecular dynamics in gastric cancer an...
ORGANISM(S): Mus Musculus 
2024-03-25 | PXD050941 |
ProteomicsSUMOylation-Induced Membrane Localization of TRPV1 Suppresses Proliferation and Migration in Gastric Cancer Cells
In this work, we elucidate a novel mechanism wherein TRPV1 SUMOylation promotes its membrane expression and activates the TRPV1-Ca2+-AMPK signaling pathway, thereby inhibiting GC cell proliferation and migration. These findings enhance our understanding of the molecular dynamics in gastric cancer an...
ORGANISM(S): Homo Sapiens 
2024-03-25 | PXD050942 |
ProteomicsLoss of Fbxo45 in AT2 cells leads to insufficient histone supply and initiates lung adenocarcinoma
We identified proteins that interact with FBXO45 and UPF1 through mass spectrometry.
ORGANISM(S): Homo Sapiens 
2024-10-29 | PXD057326 |
ProteomicsHypoxia Regulates Overall mRNA Homeostasis by Inducing Met1-linked Linear Ubiquitination of AGO2 in Cancer Cells
Hypoxia is the most prominent feature in human solid tumors and induces activation of hypoxia-inducible factors and their downstream genes to promote cancer progression. However, whether and how hypoxia regulates overall mRNA homeostasis is unclear. Here we show that hypoxia inhibits global-mRNA dec...
ORGANISM(S): Homo Sapiens 
2021-04-06 | PXD021722 |
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