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ProteomicsThe Phenyl Indole p97 inhibitor, UPCDC-30245, blocks endo-lysosomal degradation and coronavirus entry to host cells
Different modes of action small molecule inhibitors provide versatile tools for investigation of biology and development of therapeutics. However, to evaluate their exact mechanism of actions remains to be a challenging tas. We have identified two classes of p97 inhibitors, ATP competitive and allos...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD025822 | Pride
P97 inhibitor  proteomic  anti-virus 
Proteomicsp97/VCP as a therapy target for developing drugs against human coronavirus
Understanding how human coronavirus dysregulate host proteome during infection in human cells will identify general pathways that are common to coronavirus infection. NMS-873 is an allosteric p97/VCP ATPase inhibitor and was show to have antiviral effect in multiple viruses including SARS-CoV2. We f...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD026216 | Pride
Cornoavirus Proteomic P97 
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