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TranscriptomicsThe differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97
A possible functional role of VCP/p97 during differentiation of U937 cells was addressed by siRNA-targeting of VCP/p97. Functional changes in VCP-siRNA-transfected cells following phorbol ester-induced monocytic differentiation have been examind by DNA microarray analysis. Cells transfected with the...
ORGANISM(S): Homo sapiens 
2010-06-29 | E-GEOD-9821 | biostudies-arrayexpress
ProteomicsAP-SWATH analysis reveals a direct involvement of VCP/p97 in integrated stress response signalling through CReP/PPP1R15B degradation
The ubiquitin-directed AAA-ATPase VCP/p97 facilitates degradation of misfolded proteins in diverse cellular stress response pathways. Resolving the complexity of dynamic interactions with hosts of accessory proteins and substrates has therefore been a major challenge. Here, we used affinity-purifica...
ORGANISM(S): Homo sapiens (Human) 
2018-04-04 | PXD007876 | Pride
Integrated stress response Ap-swath P97 
ProteomicsFAF2 enhances unfoldase activity of mammalian p97-UFD1-NPL4 complex enabling rational design of p97
To address how adaptor proteins impact human p97 activity, we here employ in vitro reconstitution and a focused biochemical screen to identify adaptors that enhance unfoldase activity of human p97 in the presence of UFD1-NPL4. Of the adaptors tested, Fas-associated factor 2 (FAF2/UBXD8), a UBX domai...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD073479 | Pride
Faf2 Hdx-ms P97 
GenomicsProteus vulgaris P97
Draft genome of Proteus vulgaris P97
PRJEB9438 | ENA
TranscriptomicsRNAi knock down of VCP in human HeLa cells
Study of the effects of the VCP knockdown. VCP (p97, yeast cdc48) is a hexameric AAA ATPase involved in various cellular functions including degradation of proteins by the ubiquitin-proteasome system. We examine the consequences of the reduction of VCP levels after RNAi of VCP in HeLa cells. We find...
ORGANISM(S): Homo sapiens 
2006-08-23 | E-MEXP-817 | biostudies-arrayexpress
ProteomicsImmunoprecipitation of p97 from X.laevis S-phase chromatin
Complex cellular processes are driven by the regulated assembly and disassembly of large multi-protein complexes. In eukaryotic DNA replication, whilst we are beginning to understand the molecular mechanism for assembly of the replication machinery (replisome), we still know little about the regulat...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-10-14 | PXD029705 | Pride
Vcp Replisome disassembly Xenopus laevis P97 Dna replication 
ProteomicsVCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates
The hexameric AAA+ ATPase p97/VCP functions as an essential mediator of ubiquitin-dependent cellular processes, extracting ubiquitylated proteins from macromolecular complexes or membranes by catalyzing their unfolding. p97 is directed to ubiquitylated client proteins via multiple cofactors, most of...
ORGANISM(S): Homo sapiens (Human) 
2024-03-14 | PXD043563 | Pride
Fam104a Vcf Vcp Ubiquitin P97 
GenomicsPhaeobacter porticola strain:P97
Phaeobacter porticola strain:P97 Genome sequencing and assembly
PRJNA327072 | ENA
TranscriptomicsHCT116 cells treated with the p97 inhibitior CB-5083
The goal of this study was to analyze differential gene expression 8 hr after treatment of CB-5083, a small molecule inhibitor of p97 (VCP), in HCT116 cells grown in culture. DMSO treated cells were compared to cells treated with 1uM CB-5083 after 8 hr.
ORGANISM(S): Homo sapiens 
2015-11-09 | E-GEOD-73588 | biostudies-arrayexpress
Proteomicsp97/VCP promotes the recycling of endocytic cargo
The endocytic pathway is of central importance for eukaryotic cells, as it enables uptake of extracellular materials, membrane protein quality control and recycling, as well as modulation of receptor signaling. While the ATPase p97 (VCP, Cdc48) has been found to be involved in the fusion of early en...
ORGANISM(S): Homo sapiens (Human) 
2023-09-28 | PXD041169 | Pride
Myof Myoferlin Vcp Cdc48 P97 Rab11 
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