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ProteomicsFAF2 enhances unfoldase activity of mammalian p97-UFD1-NPL4 complex enabling rational design of p97
To address how adaptor proteins impact human p97 activity, we here employ in vitro reconstitution and a focused biochemical screen to identify adaptors that enhance unfoldase activity of human p97 in the presence of UFD1-NPL4. Of the adaptors tested, Fas-associated factor 2 (FAF2/UBXD8), a UBX domai...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD073479 | Pride
Faf2 Hdx-ms P97 
ProteomicsFAF1 and FAF2 enhance human p97-UFD1-NPL4 complex unfoldase activity enabling rational design of p97 activators - Crosslinking mass spec data
VCP/p97 is an AAA+ ATPase that, together with its cofactors UFD1-NPL4 (p97-UN), binds and unfolds ubiquitylated substrates to maintain cellular homeostasis. The human p97-UN complex associates with additional cofactors, but how these cofactors modulate p97-UN activity is not fully understood. We scr...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD078865 | Pride
Atpase Xl-ms Faf2 Ufd1 Vcp Npl4 P97 
GenomicsKnockdown of FAF2 Prevents Alcohol-Induced Steatosis in Mouse Liver
Knockdown of FAF2 Prevents Alcohol-Induced Steatosis in Mouse Liver
PRJNA1127643 | ENA
GenomicsFaf2 is required for neural differentiation in embryonic neural progenitor cells
Faf2 is required for neural differentiation in embryonic neural progenitor cells
PRJNA1494588 | ENA
TranscriptomicsKnockdown of FAF2 Prevents Alcohol-Induced Steatosis in Mouse Liver
Alcohol is metabolized in the liver, and chronic consumption can lead to inflammation, scarring, and damage to liver cells. The pathogenesis of alcoholic liver disease (ALD), a complicated condition, is characterized by a succession of histopathological alterations that occur through a multistep and...
ORGANISM(S): Mus musculus 
2025-02-26 | GSE270659 | GEO
UnknownPolyserine-mediated targeting of FAF2/UBXD8 ameliorates tau aggregation.
Not available
S-EPMC12422715 | biostudies-literature
GenomicsTranscriptomic profiling of liver and skeletal muscle from high-fat diet-fed intestine-specific Faf2 knockout mice
Transcriptomic profiling of liver and skeletal muscle from high-fat diet-fed intestine-specific Faf2 knockout mice
PRJNA1517566 | ENA
TranscriptomicsFaf2 is required for neural differentiation in embryonic neural progenitor cells
Neural progenitor cell differentiation is a complex process requiring the proper integration of instructive and permissive factors. Instructive cues including signaling molecules and transcription factor networks have been well studied in this context, but permissive factors such as cell homeostasis...
ORGANISM(S): Mus musculus 
2026-07-30 | GSE338508 | GEO
TranscriptomicsTranscriptomic profiling of liver and skeletal muscle from high-fat diet-fed intestine-specific Faf2 knockout mice
This study investigated transcriptomic changes associated with intestine-specific Faf2 deficiency in male mice fed a high-fat diet (HFD). RNA sequencing was performed on liver and gastrocnemius skeletal muscle collected from intestine-specific Faf2 knockout (Faf2-IKO) mice and littermate controls. T...
ORGANISM(S): Mus musculus 
2026-08-24 | GSE344826 | GEO
UnknownSilencing FAF2 mitigates alcohol-induced hepatic steatosis by modulating lipolysis and PCSK9 pathway.
Not available
S-EPMC11841855 | biostudies-literature
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