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GenomicsMetamycoplasma hyosynoviae strain:NPL4
Mycoplasma hyosynoviae NPL4 Genome sequencing
PRJNA238376 | ENA
ProteomicsFAF2 enhances unfoldase activity of mammalian p97-UFD1-NPL4 complex enabling rational design of p97
To address how adaptor proteins impact human p97 activity, we here employ in vitro reconstitution and a focused biochemical screen to identify adaptors that enhance unfoldase activity of human p97 in the presence of UFD1-NPL4. Of the adaptors tested, Fas-associated factor 2 (FAF2/UBXD8), a UBX domai...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD073479 | Pride
Faf2 Hdx-ms P97 
UnknownStructural insights into the p97-Ufd1-Npl4 complex.
Not available
S-EPMC1761865 | biostudies-literature
ProteomicsTargeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast
In eukaryotes, the conjugation of proteins to the small ubiquitin-like modifier SUMO regulates numerous cellular functions. A proportion of SUMO conjugates are targeted for degradation by SUMO-targeted ubiquitin ligases (STUbLs) and it has been proposed that the ubiquitin-selective chaperone Cdc48/p...
ORGANISM(S): Schizosaccharomyces pombe 
2015-10-30 | PXD002972 | Pride
Lc-msms S. pombe Stubl Cdc48-ufd1-npl4 Sumo modification sites 
ProteomicsInduced degradation of Ufd1 reveals regulation of cohesin by the VCP/p97Ufd1-Npl4 complex
The AAA ATPase VCP/p97 has emerged as a critical regulator of ubiquitin and chromatin-associated processes but progress in understanding has been hampered by the complexity of p97 functions and the various p97 cofactors involved. Here, we combined ubiquitin profiling with acutely induced degradation...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD082712 | Pride
Dna damage Replication Ubiquitin Vcp Cohesin 
UnknownStructural insights into ubiquitin recognition and Ufd1 interaction of Npl4.
Not available
S-EPMC6910952 | biostudies-literature
TranscriptomicsDisulfiram/Copper induces immunogenic cell death via NPL4 in hepatocellular carcinoma
Some chemotherapeutic agents have been found to enhance the antitumor immunity by inducing immunogenic cell death (ICD). The combination of disulfiram (DSF) and copper (Cu) has demonstrated anti-tumor effects in a range of malignancies including hepatocellular carcinoma (HCC). However, the potential...
ORGANISM(S): Homo sapiens 
2022-10-19 | GSE211734 | GEO
ProteomicsA Non-symmetrical p97 Conformation Favors Ufd1/Npl4 Recruitment
p97/Cdc48 is a hexameric AAA ATPase in which each monomer consists of an N-terminal domain (NTD) and two ATPase domains (D1 and D2), which cooperate in substrate recruitment and processing. In vitro experiments and cryo-EM structures of p97 and its cofactor, Ufd1/Npl4 (UN), revealed mechanistic insi...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2024-05-16 | PXD045179 | Pride
Atpase Xl lc-ms/ms P97/vcp 
ProteomicsFAF1 and FAF2 enhance human p97-UFD1-NPL4 complex unfoldase activity enabling rational design of p97 activators - Crosslinking mass spec data
VCP/p97 is an AAA+ ATPase that, together with its cofactors UFD1-NPL4 (p97-UN), binds and unfolds ubiquitylated substrates to maintain cellular homeostasis. The human p97-UN complex associates with additional cofactors, but how these cofactors modulate p97-UN activity is not fully understood. We scr...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD078865 | Pride
Atpase Xl-ms Faf2 Ufd1 Vcp Npl4 P97 
UnknownStructure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4.
Not available
S-EPMC6044470 | biostudies-literature
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