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TranscriptomicsThe differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97
A possible functional role of VCP/p97 during differentiation of U937 cells was addressed by siRNA-targeting of VCP/p97. Functional changes in VCP-siRNA-transfected cells following phorbol ester-induced monocytic differentiation have been examind by DNA microarray analysis. Cells transfected with the...
ORGANISM(S): Homo sapiens 
2010-06-29 | E-GEOD-9821 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of VCP in human HeLa cells
Study of the effects of the VCP knockdown. VCP (p97, yeast cdc48) is a hexameric AAA ATPase involved in various cellular functions including degradation of proteins by the ubiquitin-proteasome system. We examine the consequences of the reduction of VCP levels after RNAi of VCP in HeLa cells. We find...
ORGANISM(S): Homo sapiens 
2006-08-23 | E-MEXP-817 | biostudies-arrayexpress
ProteomicsVCP–adaptor interactions are exceptionally dynamic and subject to differential modulation by a VCP inhibitor
In this study we use a combination of mass spectrometry-based proteomics and biophysical studies to characterize the interaction of adaptors with VCP. Our results reveal that most VCP–adaptor interactions are characterized by exceptionally rapid dynamics that in some cases are modulated by the VCP i...
ORGANISM(S): Homo sapiens (Human) 
2016-07-18 | PXD004105 | Pride
Ap-ms Sec-ms Vcp/p97 Protein complex dynamics Crosslinking-ms Orbitrap 
ProteomicsBTG3-dependent VCP/p97 nuclear translocation is required for efficient repair of UV-induced DNA lesions
Skin exposure to ultraviolet (UV) rays from sunlight results in the formation of mutagenic DNA photolesions that are repaired by the nucleotide excision repair (NER) machinery. The inefficient repair of photolesions can lead to stalled DNA replication and mispairing, thereby causing strand breaks an...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD056446 | Pride
Phosphorylation Lc-ms/ms 
ProteomicsHuman VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB
Microglia play crucial roles in mediating neuronal homeostasis but have been implicated in contributing to amyotrophic lateral sclerosis (ALS). However, the role of microglia in ALS remains incompletely understood. Here, we generated highly enriched cultures of VCP mutant microglia derived from huma...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057586 | Pride
Human Ipsc Als Ftd Microglia Lc-ms/ms 
ProteomicsProteins co-localized with RNA Pol2 in ALS patient-derived neural precursors
Deficiency of proteostasis and RNA metabolism are increasingly recognized as critical drivers of neurodegenerative diseases. In this study, we focused on RNA polymerase II (Pol2) as the converging point of these two elements to understand how transcriptional machinery is affected by ALS-associated V...
ORGANISM(S): Homo Sapiens (human) 
2023-03-02 | PXD034483 | JPOST Repository
GenomicsProteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function
Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function
PRJNA419745 | ENA
GenomicsASPSCR1-TFE3 reprograms transcription by organizing enhancers around hexameric VCP [ASPS1 VCP ChIP]
ASPSCR1-TFE3 reprograms transcription by organizing enhancers around hexameric VCP [ASPS1 VCP ChIP]
PRJNA682753 | ENA
TranscriptomicsExpression profiling in VCP-associated myopathy
Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia (IBMPFD) is caused by mutations in the Valosin Containing Protein (VCP) gene on chromosome 9p12-13. To elucidate affected signaling transduction axes in IBMPFD, we determined expression profiles using microarra...
ORGANISM(S): Homo sapiens 
2012-07-18 | E-GEOD-30806 | biostudies-arrayexpress
ProteomicsVCP enhances autophagy-related osteosarcoma progression by recruiting USP2 to inhibit ubiquitination and degradation of FASN
The mass spectrometry data were acquired using a Q Exactive HF mass spectrometer coupled with an UltiMate 3000 RSLCnano liquid chromatography system. Peptide samples were dissolved in a loading buffer, introduced via an autosampler, and separated on an analytical column (75 μm × 25 cm, C18, 1.9 μm, ...
ORGANISM(S): Homo Sapiens 
PXD055763 |
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