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ProteomicsTargeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast
In eukaryotes, the conjugation of proteins to the small ubiquitin-like modifier SUMO regulates numerous cellular functions. A proportion of SUMO conjugates are targeted for degradation by SUMO-targeted ubiquitin ligases (STUbLs) and it has been proposed that the ubiquitin-selective chaperone Cdc48/p...
ORGANISM(S): Schizosaccharomyces pombe 
2015-10-30 | PXD002972 | Pride
Lc-msms S. pombe Stubl Cdc48-ufd1-npl4 Sumo modification sites 
UnknownStructure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4.
Not available
S-EPMC6044470 | biostudies-literature
UnknownSUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Not available
S-EPMC9910466 | biostudies-literature
UnknownUfd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication.
Not available
S-EPMC5382235 | biostudies-literature
UnknownProteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length.
Not available
S-EPMC4579843 | biostudies-literature
UnknownTargeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Not available
S-EPMC4667616 | biostudies-literature
ProteomicsTranslocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase
The hexameric Cdc48 ATPase (p97 or VCP in mammals) cooperates with its cofactor Ufd1/Npl4 to extract polyubiquitinated proteins from membranes or macromolecular complexes for degradation by the proteasome. Here, we clarify how the Cdc48 complex unfolds its substrates and translocates polypeptides wi...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-01-19 | PXD027639 | Pride
Hydrogen deuterium exchange mass spectrometry Npl4 Unfolding Ufd1 Translocation Ubiquitin Vcp Hdx-ms P97 Aaa atpase 
UnknownDoa1 targets ubiquitinated substrates for mitochondria-associated degradation.
Not available
S-EPMC4828692 | biostudies-literature
UnknownThe Ufd1 cofactor determines the linkage specificity of polyubiquitin chain engagement by the AAA+ ATPase Cdc48.
Not available
S-EPMC9992269 | biostudies-literature
UnknownMultiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase.
Not available
S-EPMC9377798 | biostudies-literature
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