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Targeting myoferlin in ER/Golgi vesicle trafficking reprograms cancer-associated fibroblasts in pancreatic cancer.
Pancreatic cancer cells exploit vesicle trafficking proteins such as myoferlin to fuel tumor aggressiveness, yet the presence and function of myoferlin-dependent vesicles in cancer-associated fibroblasts (CAFs) remain unknown. By combining PDAC whole-tumor and single-cell transcriptomic analyses wit...
ORGANISM(S): Homo sapiens 
2025-08-28 | GSE306772 | GEO
Bulk RNA-seq analysis of PDAC PANC-1 cells silenced with siRNA targeting myoferlin or treated with WJ460.
The Rab11a endosomal recycling pathway is exploited by important respiratory RNA viruses such as IAV and RSV, aiding viral egress from the apical surface of polarized epithelial cells. Late in infection, Rab11a-containing vesicles specifically transport viral ribonucleoprotein (vRNP) complexes towar...
ORGANISM(S): Homo sapiens (Human) 
2025-09-25 | PXD052709 | Pride
It has been found that A Disintergrin And Metalloproteinase 12 (ADAM12) is significantly higher in multiple tumors and it has been used as a prognostic marker for cancer progression. Several ADAM12 substrates have been identified biochemically and the role of -its proteolytic function has been expl...
ORGANISM(S): Homo sapiens (Human) 
2016-07-21 | PXD003560 | Pride
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