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MetabolomicsBacteria encode their own post-mortem protein catabolism to enable nutrient recycling
For many organisms, death is a tangible, visible event. In bacteria, death can be a natural or an induced process 1. Death permits genes conferring a survival advantage to be selected in a bacterial population. Furthermore, biomolecule recycling from dead bacteria is crucial under nutrient limitatio...
2025-01-23 | MTBLS10044 | MetaboLights
MetabolomicsCholesterol maintains the degradative capacity of lysosomes during clearance and recycling of dysfunctional mitochondria
Efficient clearance and recycling of dysfunctional mitochondria through the robust catabolic activity of lysosomes is essential for cellular health. However, how membrane lipids contribute to maintaining the degradative capacity of lysosomes remains poorly understood. Here, we show that cholesterol ...
2026-07-30 | MTBLS15181 | MetaboLights
ProteomicsGlobal Protein-Turnover Quantification in Escherichia Coli Reveals Cytoplasmic Recycling under Nitrogen Limitation
We quantify the degradation rates of 3.2k E. coli proteins under 12 conditions by combining heavy isotope labeling with complement reporter ion quantification and find that cytoplasmic proteins are recycled when nitrogen is limited.
ORGANISM(S): Escherichia coli 
2024-04-01 | PXD042444 | Pride
Isotope labeling Protein degradation Tmtpro 
GenomicsIn Vitro Transcription Recycling Assay Identifies PAF1 as a Driver of RNA Pol II Recycling
In Vitro Transcription Recycling Assay Identifies PAF1 as a Driver of RNA Pol II Recycling
PRJNA552087 | ENA
ProteomicsN-terminus of Spt16 anchors FACT to Mcm2 for parental histone recycling
Parental histone recycling is essential for the restoration of chromatin-based epigenetic information during chromatin replication; however, the specific mechanisms underlying the local recycling of parental histones remain poorly understood. Here, we reveal an unexpected role of the Spt16-N domain ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-01-26 | PXD043392 | Pride
Mcm2-7 Fact，parental histone recycling 
GenomicsPhosphorylated MED1 Links Transcription Recycling and Cancer Growth
Phosphorylated MED1 Links Transcription Recycling and Cancer Growth
PRJNA525738 | ENA
ProteomicsVAMP8 function reveals tight linkage between endocytic recycling and endocytosis
Clathrin-mediated endocytosis (CME) is a multistage process that involves the initiation and stabilization of clathrin-coated pits (CCPs) that invaginate and finally detach from the plasma membrane to form clathrin-coated vesicles (CCVs). Given that SNARE proteins are essential for downstream vesicl...
ORGANISM(S): Homo Sapiens 
2026-03-09 | PXD075425 |
ProteomicsPeptidoglycan recycling is critical for cell division, cell wall integrity and β-lactam resistance in Caulobacter crescentus
Most bacteria possess a peptidoglycan cell wall, which is continuously remodeled during cell growth and divi¬sion. The peptidoglycan (PG) fragments generated in this process are typically imported into the cell and recycles through the PG biosynthesis pathway. While the underlying pathways have been...
ORGANISM(S): Caulobacter crescentus (strain NA1000 / CB15N) 
2026-03-11 | PXD069004 | Pride
Peptidoglycan Cell wall recycling Β-lactamase 
ProteomicsProtein recycling in Bering Sea Algal incubations
Protein present in phytoplankton represents a large fraction of the organic nitrogen and carbon transported from its synthesis in surface waters to marine sediments. Yet relatively little is known about the longevity of identifiable protein in situ, or the potential modifications to proteins that oc...
ORGANISM(S): Thalassiosira pseudonana 
2017-05-19 | PXD006417 | Pride
Nitrogen cycle Diatom Protein recycling Preservation Bering sea Tandem mass spectrometry Cell death Amino acid 
GenomicsIn Vitro Transcription Recycling Assay Identifies PAF1 as a Driver of RNA Pol II Recycling
RNA Polymerase II transcriptional recycling is an underappreciated mechanism for which the required factors and contributions to overall gene expression levels are poorly understood. We describe an in vitro methodology facilitating unbiased identification of novel RNA Pol II transcriptional recyclin...
ORGANISM(S): Homo sapiens 
2021-10-07 | GSE133655 | GEO
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