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TranscriptomicsMolecular-guided therapy predictions reveal drug resistance phenotypes and treatment alternatives in malignant peripheral nerve sheath tumors
Use existing public data, cell lines and patient tumors with a personalized medicine approach to predict effective therapies for treatment of Neurofibroma tumors. Compare expression profile to reference set to identify over expressed genes that are drugable targets.
ORGANISM(S): Homo sapiens 
2014-07-22 | E-GEOD-50208 | biostudies-arrayexpress
TranscriptomicsUsing a rhabdomyosarcoma patient-derived xenograft to examine precision medicine approaches and model acquired resistance.
Original patient tumor is directly implanted in mice xenografts. Tumor is propagated to multiple mice for conduct of 6 arm treatment trials and control. Therapies are selected based on T0 and F0 genomic profiles. ICE-T refractory tumor are implanted and additional 6 arm treatment trial and control c...
ORGANISM(S): Homo sapiens 
2014-07-22 | E-GEOD-51130 | biostudies-arrayexpress
TranscriptomicsSox2 promotes malignancy in glioblastoma by regulating plasticity and astrocytic differentiation
Making use of a previously described isogenic cancer stem cells and serum differentiated cultures we show that Sox2 controls developmental stated specific programs in glioblastoma. Glioblastoma cells were cultured as control and with SOX2 knockdown to identify the scope of SOX2 interactions. The SOX...
ORGANISM(S): Homo sapiens 
2014-07-22 | E-GEOD-51441 | biostudies-arrayexpress
TranscriptomicsProspective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating precision medicine (PMed) trials
Feasibility trial to examine the ability to conduct molecular guided therapy in a geographically distributed systems within strict time constraints Canine patients were enrolled across a broad panel of tumor types where tumor samples were acquired and processed to preserve RNA quality for genomic an...
ORGANISM(S): Canis lupus 
2014-04-28 | E-GEOD-51131 | biostudies-arrayexpress
TranscriptomicsGenomic profiling of lymphomas in Canis lupus familiaris
Comparative oncology is a developing research discipline that is being used to assist our understanding of human neoplastic diseases. Companion canines are a preferred animal oncology model due to spontaneous tumor development and similarity to human disease at the pathophysiological level. We use ...
ORGANISM(S): Canis lupus familiaris 
2012-12-15 | E-GEOD-41917 | biostudies-arrayexpress
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