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TranscriptomicsNon-IG Aberrations of FOXP1 in B-Cell Malignancies Lead to an Aberrant Expression of N-Truncated Isoforms of FOXP1
The transcription factor FOXP1 is implicated in the pathogenesis of B-cell lymphomas through immunoglobulin heavy chain (IGH) locus-related chromosomal translocations leading to dysregulated expression of FOXP1. Translocations of FOXP1 with non-IG gene sequences have been also reported, but the mole...
ORGANISM(S): Homo sapiens 
2013-09-04 | E-GEOD-50514 | biostudies-arrayexpress
TranscriptomicsFibrotic Myofibroblasts Manifest Genome-Wide Derangements of Translational Control
As a group, fibroproliferative disorders of the lung, liver, kidney, heart, vasculature and integument are common, progressive and refractory to therapy. They can emerge following toxic insults, but are frequently idiopathic. Their enigmatic propensity to resist therapy and progress to organ failure...
ORGANISM(S): Homo sapiens 
2008-11-20 | E-GEOD-11196 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wheat B1118-8 4(6) line with its background control-Cadenza bread wheat line. Transcriptomes analysis was performed in endosperm tissue (14 and 28 days post anthesis-dpa) and in leaf tissue (8 days post germination dpg)
B1118-8-4 expresses five HMW subunits encoded by Glu-B1 (14, 15) and Glu D1 (5, 10) and transgene Glu-A1 (Ax1).Cadenza does not express Glu-A1 (Ax1. B111-8-8-4 (6)transgenic wheat line was produced by co-transformation with two plasmids: one of the plasmids carring the transgene HMW-GS 1Ax1 (Halford...
ORGANISM(S): Triticum aestivum 
2005-10-05 | E-MEXP-311 | biostudies-arrayexpress
TranscriptomicsThe activation potential of MOF is constrained for dosage compensation
The H4K16 acetyltransferase MOF plays a crucial role in dosage compensation in Drosophila, but has additional, global functions. We compared the molecular context and effect of MOF in male and female flies combining chromosome-wide mapping and transcriptome studies with analyses of defined reporter ...
ORGANISM(S): Drosophila melanogaster 
2010-06-26 | E-GEOD-20695 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wheat GF- Transgenic _B1355-4-2 vs CTRL_Cadenza wheat lines endosperm tissue (14 and 28 days post anthesis-dpa) and in leaf tissue (8 days post germination ?dpg)
B1355-4-2 expresses five HMW subunits encoded by Glu-B1 (14, 15) and Glu D1 (5, 10) and transgene Glu-A1 (Ax1).Cadenza does not express Glu-A1 (Ax1. Line B1355-4-2(18) was generated by co-transformation with the ?clean? fragments of the HMW-GS 1Ax1 transgene (Halford, N.G. et al. Analysis of HMW glu...
ORGANISM(S): Triticum aestivum 
2005-10-05 | E-MEXP-307 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wheat GF-transgenic-B102,1-1 vs control-L88-31 lines endosperm tissue (14 and 28 days post anthesis-dpa) and in leaf tissue (8 days post germination ?dpg)
The high molecular weight (HMW) subunits of wheat glutenin are synthesised only in the starchy endosperm tissue of the developing wheat grain. We studied the effect of introducing transgenes on the global gene expression profiles of selected transgenic wheat lines, particularly during wheat seed dev...
ORGANISM(S): Triticum aestivum 
2005-10-05 | E-MEXP-306 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wheat L88-18 line vs CTRL_L8831endosperm tissue (14 and 28 days post anthesis-dpa) and in leaf tissue (8 days post germination dpg)
The high molecular weight (HMW) subunits of wheat glutenin are synthesised only in the starchy endosperm tissue of the developing wheat grain. The transcriptomes of the lines L88-18 and L88-31 (Lawrence, G.J., Macritchie, F. & Wrigley, C.W. Dough and baking quality of wheat lines in glutenin subunit...
ORGANISM(S): Triticum aestivum 
2005-10-05 | E-MEXP-310 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wheat B102,1-1 line endosperm at 14 dpa and leaf at 8 dpg of the transgenic line
The high molecular weight (HMW) subunits of wheat glutenin are synthesised only in the starchy endosperm tissue of the developing wheat grain. To place the differences observed between the endosperms of the transgenic and non-transgenic lines in a wider developmental context, the transcriptomes of e...
ORGANISM(S): Triticum aestivum 
2005-10-05 | E-MEXP-312 | biostudies-arrayexpress
TranscriptomicsThe MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset (ChIP)
The MOF-containing NSL complex binds to many but not all promoters of active genes and potentially contributes to their proper gene expression. It is currently unknown what determines whether an active gene is bound or not. Here, we provide evidence that the NSL complex primarily targets active prom...
ORGANISM(S): Drosophila melanogaster 
2011-10-28 | E-GEOD-30989 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wheat GF- TRANS_B102,1-1 vs Conv.bred_L88-18 transgenic lines endosperm tissue (14 and 28 days post anthesis-dpa) and in leaf tissue (8 days post germination ?dpg)
The high molecular weight (HMW) subunits of wheat glutenin are synthesised only in the starchy endosperm tissue of the developing wheat grain. We compared the expressed genomes of the transgenic wheat line B102,1-1 (Rooke et al. Transgene inheritance, segregation and expression in bread wheat. Euphy...
ORGANISM(S): Triticum aestivum 
2005-10-05 | E-MEXP-309 | biostudies-arrayexpress
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