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UnknownDiscovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors.
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S-EPMC6580535 | biostudies-literature
TranscriptomicsRNA Polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA Polymerase II
Release of promoter-proximal paused RNA polymerase II (Pol II) during early elongation is a critical step in transcriptional regulation in metazoan cells. Paused Pol II release is thought to require the kinase activity of cyclin-dependent kinase 9 (CDK9) for the phosphorylation of DRB sensitivity-in...
ORGANISM(S): Homo sapiens 
2015-12-11 | E-GEOD-62171 | biostudies-arrayexpress
ProteomicsIntact-cell thermal PISA-MS target-engagement profiling of M5717 in Plasmodium falciparum
Here we demonstrate eEF1-alpha and eEF2 stabilisation by M5717 in the intact-cell P. falciparum-infected red blood cells, using thermal Proteome Integral Solubility Alteration (Thermal PISA) assay coupled with Data Independent Acquisition Mass Spectrometry (DIA-MS).
ORGANISM(S): Plasmodium (plasmodium) 
2026-02-17 | PXD059612 | JPOST Repository
GenomicsA PTIP-PA1 subcomplex promotes transcription for IgH class-switching independently from the associated MLL3/MLL4 methyltransferase complex
Class-switch recombination (CSR) diversifies antibodies for productive immune responses while maintaining stability of the B cell genome. Transcription at the immunoglobulin heavy-chain (Igh) locus targets CSRassociated DNA damage and is promoted by the BRCT domain-containing PTIP protein. Although ...
ORGANISM(S): Mus musculus 
2015-12-12 | E-GEOD-75930 | biostudies-arrayexpress
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