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Transcriptomics3-anhydro-6-hydroxy-ophiobolin A inhibits the replication of influenza A virus in vitro and in vivo
Influenza is a major cause of morbidity and mortality worldwide, and the emerging drug resistance poses an increasing challenge to the treatment of influenza virus infection. Therefore, the development of a novel antiviral drugs has become an urgent task to combat against the influenza viruses that ...
ORGANISM(S): Homo sapiens 
2015-11-05 | E-GEOD-58741 | biostudies-arrayexpress
TranscriptomicsE2F in vivo binding specificity: comparison of consensus vs. non-consensus binding sites
Recent genome-scale ChIP-chip studies of transcription factors have shown that a low percentage of experimentally determined binding sites contain the consensus motif for the immunoprecipitated factor. In most cases, differences between in vivo target sites that contain or lack a consensus motif ha...
ORGANISM(S): Mus musculus 
2008-10-01 | E-GEOD-12126 | biostudies-arrayexpress
TranscriptomicsA ChIP-chip analysis of E2F family in normal and tumor cells reveals interchangeable roles of E2F family members
Using ChIP-chip assays, we examined the binding patterns of three members of E2F family in five different cell types. Keywords: ChIP-chip We used ENCODE arrays to determine the loaction of E2F family, then identify their binding motifs in vivo. We used promoter arrays to assess the relationship of E...
ORGANISM(S): Homo sapiens 
2007-08-22 | E-GEOD-8716 | biostudies-arrayexpress
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