E2F in vivo binding specificity: comparison of consensus vs. non-consensus binding sites

ABSTRACT: Recent genome-scale ChIP-chip studies of transcription factors have shown that a low percentage of experimentally determined binding sites contain the consensus motif for the immunoprecipitated factor. In most cases, differences between in vivo target sites that contain or lack a consensus motif have not been explored. We have previously shown that most sites to which E2F family members are bound in vivo do not contain E2F consensus motifs. The main purpose of this study was to develop an understanding of how E2F binding specificity is achieved in vivo. In particular, we have addressed how E2F family members are recruited to core promoter regions that lack a consensus motif and are excluded from other regions that contain a consensus motif. Using promoter and ENCODE arrays, we have show

ORGANISM(S): Mus musculus

SUBMITTER: Alina Rabinovich 

PROVIDER: E-GEOD-12126 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress