HeLa E2F1 ChIP-chip experiments
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Mark Bieda
PROVIDER: E-GEOD-4306 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Unbiased location analysis of E2F1-binding sites suggests a widespread role for E2F1 in the human genome.
Bieda Mark M Xu Xiaoqin X Singer Michael A MA Green Roland R Farnham Peggy J PJ
Genome research 20060410 5
The E2F family of transcription factors regulates basic cellular processes. Here, we take an unbiased approach towards identifying E2F1 target genes by examining localization of E2F1-binding sites using high-density oligonucleotide tiling arrays. To begin, we developed a statistically-based methodology for analysis of ChIP-chip data obtained from arrays that represent 30 Mb of the human genome. Using this methodology, we identified regions bound by E2F1, MYC, and RNA Polymerase II (POLR2A). We f ...[more]
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