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TranscriptomicsTranscriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression (RNA-Seq data)
Noncoding RNAs (ncRNAs) are emerging as key molecules in human cancer, with the potential to serve as novel markers of disease and to reveal uncharacterized aspects of tumor biology. Here we discover 121 unannotated prostate cancerM-bM-^@M-^Sassociated ncRNA transcripts (PCATs) by ab initio assembly...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-25183 | biostudies-arrayexpress
TranscriptomicsChimeraScan: A tool for identifying chimeric transcription in sequencing data
Next Generation Sequencing technologies have enabled de novo gene fusion discovery that could reveal candidates with therapeutic significance in cancer. Here we present an open-source software package, ChimeraScan, for the discovery of chimeric transcription between two independent transcripts. Thre...
ORGANISM(S): Homo sapiens 
2011-09-01 | E-GEOD-29098 | biostudies-arrayexpress
GenomicsDNA methylation analysis of prostate cancer cell lines and tissues using Next Generation Sequencing
Beginning with precursor lesions, aberrant DNA methylation marks the entire spectrum of prostate cancer progression. We mapped the global DNA methylation patterns in prostate tissues (n=17) and cells (n=2) from fifty nanograms of genomic DNA using Methylplex-Next Generation Sequencing (M-NGS). A...
ORGANISM(S): Homo sapiens 
2011-05-09 | E-GEOD-27618 | biostudies-arrayexpress
GenomicsChIP-Seq analysis of ER binding sites in MCF7 breast cancer cells
Estrogen Receptor (ER) is a hormonal transcription factor that plays important roles in breast cancer. It functions primarily through binding to the regulatory regions of target genes containing the consensus ERE motifs. In order to identify ER target genes and re-define the ERE motifs we performed...
ORGANISM(S): Homo sapiens 
2010-02-01 | E-GEOD-19013 | biostudies-arrayexpress
TranscriptomicsIntegrative Molecular Concepts Modeling of Prostate Cancer Progression
Using laser capture microdissection to isolate over 100 specific cell populations, we report the profiling of prostate cancer progression from benign epithelium to metastatic disease. By analyzing these expression signatures in the context of over 15,000 â??molecular conceptsâ??, or sets of biologic...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-6099 | biostudies-arrayexpress
TranscriptomicsRNA-Seq anlalysis of prostate cancer cell lines using Next Generation Sequencing
Beginning with precursor lesions, aberrant DNA methylation marks the entire spectrum of prostate cancer progression. We mapped the global DNA methylation patterns in selected prostate tissues and cell lines using Methylplex-Next Generation Sequencing (M-NGS). Hidden Markov Model based next generatio...
ORGANISM(S): Homo sapiens 
2011-05-09 | E-GEOD-29155 | biostudies-arrayexpress
ProteomicsTargeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer
Prostate cancer is driven by oncogenic transcription factor enhanceosomes comprising chromatin and epigenetic regulators. The lysine acetyltransferases p300 and CBP are key cofactors that activate enhancers through histone acetylation. Here, we identify p300/CBP-mediated multisite acetylation of the...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD065292 | Pride
Acetyl-lysine proteomics Prostate cancer P300/cbp Protac degrader 
UnknownTargeting Androgen Receptor and DNA Repair in Metastatic Castration-Resistant Prostate Cancer: Results From NCI 9012.
Not available
S-EPMC6075827 | biostudies-literature
GenomicsDNA Methylation Analysis of Prostate Cancer Cell Lines and Tissues Using Next Generation Sequencing

Aberrant DNA methylation changes are known to occur during prostate cancer progression beginning with precursor lesions. Utilizing fifty nanograms of genomic DNA in Methylplex-Next Generation Sequencing (M-NGS) we mapped the global DNA methylation patterns in prostate tissues (n=17) and cells (n=...

phs000597.v1.p1 | EGA
ProteomicsTargeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer
Prostate cancer is driven by oncogenic transcription factor enhanceosomes comprising chromatin and epigenetic regulators. The lysine acetyltransferases p300 and CBP are key cofactors that activate enhancers through histone acetylation. Here, we identify p300/CBP-mediated multisite acetylation of the...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD065228 | Pride
Prostate cancer Protac degrader cbpd-409 P300/cbp 
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