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MetabolomicsFrom maternal metabolome to placental development: thiamine-driven placental Notch-PI3K/AKT pathway coordinates placental angiogenesis and nutrient transport
Maternal supplementation with thiamine during gestation and lactation promotes placental development and enhances offspring growth through activation of the Notch signaling pathway.
2025-07-30 | MTBLS12796 | MetaboLights
GenomicsRescue of chloride and bicarbonate transport by elexacaftor-ivacaftor-tezacaftor in organoid-derived CF intestinal and cholangiocyte monolayers
Rescue of chloride and bicarbonate transport by elexacaftor-ivacaftor-tezacaftor in organoid-derived CF intestinal and cholangiocyte monolayers
PRJNA755978 | ENA
TranscriptomicsRescue of chloride and bicarbonate transport by elexacaftor-ivacaftor-tezacaftor in organoid-derived CF intestinal and cholangiocyte monolayers
In cystic fibrosis (CF), loss of CF transmembrane conductance regulator (CFTR)-dependent bicarbonate secretion precipitates the accumulation of viscous mucus in the lumen of respiratory and gastrointestinal epithelial tissues. We investigated whether the combination of elexacaftor (ELX), ivacaftor (...
ORGANISM(S): Homo sapiens 
2021-12-14 | GSE182347 | GEO
UnknownChloride transport modulators as drug candidates.
Not available
S-EPMC8714991 | biostudies-literature
TranscriptomicsThe kidney collecting duct acid-base regulon
Kidneys are essential for acid-base homeostasis, especially when organisms cope with changes in acid or base dietary intake. Because collecting ducts constitute the final site for regulating urine acid-base balance, we undertook to identify the gene network involved in acid-base transport and regula...
ORGANISM(S): Mus musculus 
2006-07-01 | E-GEOD-4729 | biostudies-arrayexpress
UnknownConformationally Flexible Cleft Receptor for Chloride Anion Transport.
Not available
S-EPMC10249377 | biostudies-literature
TranscriptomicsIon Transporter NKCC1 - Modulator of Neurogenesis in Murine Olfactory Neurons
Olfaction is one of the most crucial senses for vertebrates regarding foraging and social behavior. Therefore, it is of particular interest to investigate the sense of smell, its function on a molecular level, the signaling proteins involved in the process and the mechanism of required ion transport...
ORGANISM(S): Mus musculus 
2015-05-07 | E-GEOD-65388 | biostudies-arrayexpress
TranscriptomicsThe Arabidopsis copper transport protein COPT2 and the responses under copper and iron deficiency.
Copper and iron are essential micronutrients for most living organisms because they participate as cofactors in biological processes including respiration, photosynthesis and oxidative stress protection. In many eukaryotic organisms, including yeast and mammals, copper and iron homeostases are highl...
ORGANISM(S): Arabidopsis thaliana 
2013-06-05 | E-GEOD-42642 | biostudies-arrayexpress
UnknownChloride Selective, Nonprotonophoric Ion Transport with Macrocyclic Halogen Bonding Anionophores.
Not available
S-EPMC12319357 | biostudies-literature
UnknownEpithelial Chloride Transport by CFTR Requires TMEM16A.
Not available
S-EPMC5622110 | biostudies-literature
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