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ProteomicsA covalent fragment screen identifies ferroptosis induced by GPX4 inhibition as a vulnerability of senescent cells
Senescent cells drive ageing and age-related pathologies, including cancer. Consequently, senolytics, drugs that selectively kill senescent cells, have a broad therapeutic appeal. Here, we report a senolytic screen of a library of 10,480 covalent fragments. Amongst 44 identified hits, we found a ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD068572 | Pride
Gpx4 Rsl3 Cancer Senescence Covalent fragments Ferroptosis Senolytics One-two punch Covalent inhibitors Chloroacetamides 
ProteomicsA covalent fragment screen identifies ferroptosis induced by GPX4 inhibition as a vulnerability of senescent cells
Senescent cells drive ageing and age-related pathologies, including cancer. Consequently, senolytics, drugs that selectively kill senescent cells, have a broad therapeutic appeal. Here, we report a senolytic screen of a library of 10,480 covalent fragments. Amongst 38 identified hits, we found a sub...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD068417 | Pride
Gpx4 Rsl3 Cancer Senescence Chloroacetamides Covalent fragments Ferroptosis Senolytics One-two punch Covalent inhibitors 
UnknownPalladium-catalyzed α-arylation of 2-chloroacetates and 2-chloroacetamides.
Not available
S-EPMC3668638 | biostudies-literature
UnknownPd-catalyzed alkynylation of 2-chloroacetates and 2-chloroacetamides with potassium alkynyltrifluoroborates.
Not available
S-EPMC3820111 | biostudies-literature
UnknownNovel 1-[5-(4-bromophenoxy)pentyl]-3-(2-arylamino- 2-oxoethyl)uracils and their antiviral properties
Not available
S-EPMC7148871 | biostudies-literature
UnknownStructure-activity relationships of GPX4 inhibitor warheads.
Not available
S-EPMC8006158 | biostudies-literature
UnknownSynthesis, Characterization, and Crystal Structure of Some New Tetrahydroisoquinolines and Related Tetrahydrothieno[2,3-c]isoquinolines.
Not available
S-EPMC8015126 | biostudies-literature
UnknownExploration of Dihydrothieno[2,3-c] Isoquinolines As Luminescent Materials and Corrosion Inhibitors.
Not available
S-EPMC9631879 | biostudies-literature
UnknownEvidence of a Distinctive Enantioselective Binding Mode for the Photoinduced Radical Cyclization of α-Chloroamides in Ene-Reductases.
Not available
S-EPMC10696551 | biostudies-literature
UnknownSulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry.
Not available
S-EPMC9936582 | biostudies-literature
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