Sort   by:  
 Page size 
MetabolomicsDifferential Metabolites and Disturbed Metabolic Pathways Associated with chlorpromazine Poisoning
Not available
ORGANISM(S): Mus musculus 
ST001739 | MetabolomicsWorkbench
TranscriptomicsPHH Chlorpromazine
Drug induced liver injury (DILI) is still a major reason for drug attrition during clinical trials and market-withdrawal of already approved drugs. DILI is difficult to predict in animal models, hence more suitable screening methods are needed to predict adverse effects in human. Here, transcriptom...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-MTAB-1747 | biostudies-arrayexpress
MetabolomicsIdentifying Candidate Differential Metabolites in lethal chlorpromazine poisoning Relative to non-drug related deaths (part III)
Not available
ORGANISM(S): Mus musculus 
ST001781 | MetabolomicsWorkbench
TranscriptomicsRNA-seq of wild-type Salmonella Typhimurium SL1344 in the presence and absence of chlorpromazine or Phe-Arg-Beta-Napthylamide
The aim of this experiment was to determine the changes in transcription caused by inhibition of efflux pumps by the Phe-Arg-Beta-Naptylamide (PABN) and chlorpromazine. Four biological replicates per condition were grown to mid-log phase in MOPS minimal media (OD600) and were exposed to the known ef...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2020-06-01 | E-MTAB-8190 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse frontal cortex after treatment with zntipsychotic drugs
Antipsychotic drugs are classified as typical and atypical based on extrapyramidal effects. However, since the frontal cortex is one of the most important regions for antipsychotic actions, this study attempted to classify antipsychotic drugs based on gene expression in the frontal cortex. Chlorprom...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-1501 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human monocyte-derived macrophages in response to Salmonella infection and Chlorpromazine treatment
RNA-seq was performed to determine the transcriptional response of human monocyte-derived macrophages to Salmonella infection and whether Chlorpromazine affected this response. These data were used to determine whether enhanced killing capacity of Chlorpromazine treated cells was due to transcriptio...
ORGANISM(S): Homo sapiens 
2023-01-01 | E-MTAB-7232 | biostudies-arrayexpress
TranscriptomicsEffect of Chlorpromazine HCl on Rat Primary Hepatocytes.
This study provides an evaluation of changes in gene expression associated with chlorpromazine HCl treatment of rat hepatocytes in vitro. Primary rat hepatocytes were treated for 24 and 48 hours with two doses (0.8 uM and 20 uM) of chlorpromazine HCl and 1% DMSO vehicle control. Five replicates of ...
ORGANISM(S): Rattus norvegicus 
2012-08-28 | E-GEOD-40341 | biostudies-arrayexpress
TranscriptomicsEffect of Chlorpromazine HCl on Rat Primary Hepatocytes.
This study provides an evaluation of changes in gene expression associated with chlorpromazine HCl treatment of rat hepatocytes in vitro. Primary rat hepatocytes were treated for 24 and 48 hours with two doses (0.8 uM and 20 uM) of chlorpromazine HCl and 1% DMSO vehicle control. Five replicates of e...
ORGANISM(S): Rattus norvegicus 
2012-08-28 | GSE40341 | GEO
GenomicsRNA-seq of human monocyte-derived macrophages in response to Salmonella infection and Chlorpromazine treatment
RNA-seq of human monocyte-derived macrophages in response to Salmonella infection and Chlorpromazine treatment
PRJEB28767 | ENA
TranscriptomicsCharacteristic molecular and proteomic signatures of drug-induced liver injury in a rat model
we assessed characteristic molecular and proteomic signatures in rat liver treated with drugs (pyrazinamide, ranitidine, enalapril, carbamazepine, and chlorpromazine) that are known to cause DILI in humans. In the present study, we assessed the characteristic gene expression signature for DILI in a ...
ORGANISM(S): Rattus norvegicus 
2013-08-16 | E-GEOD-49631 | biostudies-arrayexpress
Sort   by:  
 Page size