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UnknownIdentification and targeting leukemia stem cells: The path to the cure for acute myeloid leukemia.
Not available
S-EPMC4172676 | biostudies-literature
TranscriptomicsDeterminants of sensitivity to DZNep induced apoptosis in multiple myeloma cells
The 3-Deazaneplanocin A (DZNep), one of S-adenosylhomocysteine (AdoHcy) hydrolase inhibitors, has shown antitumor activities in a broad range of solid tumors and acute myeloid leukemia. Here, we examined its effects on multiple myeloma (MM) cells and found that, at 500 nM, it potently inhibited grow...
ORGANISM(S): Homo sapiens 
2011-07-04 | E-GEOD-26921 | biostudies-arrayexpress
TranscriptomicsCombination of ABT-869 with SAHA on AML with FLT3-ITD
For the microarray experiments, MV4-11 and MOLM-14 cells were treated with DMSO control, ABT-869 3 nM, SAHA 6 M and combination therapy for 24 hours. Cells were then washed in PBS and high-quality total RNA was extracted RNeasy Midi Kit, according to the manufacturer’s instruction (Qiagen, Valencia...
ORGANISM(S): Homo sapiens 
2011-05-31 | E-GEOD-26114 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiling of NKTCL (Natural Killer/T-Cell Lymphoma) samples
We performed a comprehensive genome-wide miRNA expression profiling (MEP) of extranodal nasal-type Natural Killer/T-cell lymphoma (NKTL) using formalin fixed paraffin-embedded tissue (FFPE) (n=30) and NK cell lines (n=6) in comparison with normal NK cells, with the objective of understanding the pat...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-31377 | biostudies-arrayexpress
UnknownEfficacy and safety of front-line treatment regimens for Waldenstrom macroglobulinaemia: a systematic review and meta-analysis.
Not available
S-EPMC10485051 | biostudies-literature
TranscriptomicsMEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma (SCC)
Genomic analyses of SCC have yet to yield significant strategies against pathway activation to improve treatment. Platinum-based chemotherapy remains the mainstay of treatment for SCC of different histotypes either as a single agent or alongside other chemotherapeutic drugs or radiotherapy; however,...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-66549 | biostudies-arrayexpress
ProteomicsE3 ligase TRIP12 affecting EZH2 ubiquitination in ENKTL
Effects of potential E3 ligase that mediates polyubiquitination of EZH2 in extranodal natural killer T cell lymphoma
ORGANISM(S): Homo Sapiens 
2023-10-14 | PXD046145 |
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