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TranscriptomicsAffect of liver transcriptome by acute acetaminophen exposure
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-05-03 | E-GEOD-42182 | biostudies-arrayexpress
TranscriptomicsSystems biology of interstitial lung diseases
This SuperSeries is composed of the following subset Series: GSE21369: Gene expression profiles of interstitial lung disease (ILD) patients GSE21394: MicroRNA expression profiles of interstitial lung disease (ILD) patients Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-04-19 | E-GEOD-21411 | biostudies-arrayexpress
TranscriptomicsThe responses of astrocytes stimulated by extracellular a-synuclein
Abnormal neuronal aggregation of a-synuclein is implicated in the development of Parkinson’s disease. Glial cells also show extensive a-synuclein pathology and are thought to contribute to disease progression. However, the mechanism that produces the glial a-synuclein pathology and the interaction b...
ORGANISM(S): Rattus norvegicus 
2010-01-11 | E-GEOD-11574 | biostudies-arrayexpress
TranscriptomicsAffect of liver transcriptome by acute acetaminophen exposure [mRNA]
To study the global changes of liver transcriptome after acetaminophen overdose. To study the global changes of transcriptome in the liver after acetaminophen overdose. Eight week old female C57BL/6 mice were fasted for 24 hours prior to a single intraperitoneal injection of 350mg/kg of acetaminoph...
ORGANISM(S): Mus musculus 
2013-05-03 | E-GEOD-42178 | biostudies-arrayexpress
TranscriptomicsAffect of liver transcriptome by acute acetaminophen exposure [miRNA]
To study the global changes of liver transcriptome after acetaminophen overdose. To study the global changes of transcriptome in the liver after acetaminophen overdose. Eight week old female C57BL/6 mice were fasted for 24 hours prior to a single intraperitoneal injection of 350mg/kg of acetaminoph...
ORGANISM(S): Mus musculus 
2013-05-03 | E-GEOD-42181 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of interstitial lung disease (ILD) patients
The mechanisms and molecular pathways underlying interstitial lung diseases (ILDs) are poorly understood. Systems biology approaches were used to identify perturbed networks in these disease states to gain a better understanding of the underlying mechanisms of disease. Through profiling genes and mi...
ORGANISM(S): Homo sapiens 
2011-03-24 | E-GEOD-21369 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiles of interstitial lung disease (ILD) patients
The mechanisms and molecular pathways underlying interstitial lung diseases (ILDs) are poorly understood. Systems biology approaches were used to identify perturbed networks in these disease states to gain a better understanding of the underlying mechanisms of disease. Through profiling genes and mi...
ORGANISM(S): Homo sapiens 
2011-04-19 | E-GEOD-21394 | biostudies-arrayexpress
TranscriptomicsGene expression networks in COPD: microRNA and mRNA regulation
70 miRNAs and 2667 mRNAs were differentially expressed between lung tissue from subjects with COPD and smokers without COPD. miRNA and mRNA expression profiles enriched for biological pathways that may be relevant to the pathogenesis of COPD including the transforming growth factor b, Wnt and focal ...
ORGANISM(S): Homo sapiens 
2012-06-26 | E-GEOD-38974 | biostudies-arrayexpress
MetabolomicsSnail reprograms glucose metabolism by repressing PFKP allowing cancer cell survival under metabolic stress
Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP) during epithelial-mesenchymal transition (EMT) is not well-understood. Here we show that Snail (SNAI1), a key transcriptional repressor of EMT, regulates glucose flux toward PPP, allowing cancer cel...
2017-11-07 | MTBLS387 | MetaboLights
ProteomicsJUMPg: an Integrative Proteogenomics Pipeline Identifying Unannotated Proteins in Human Brain and Cancer Cells
Proteogenomics is an emerging approach to improve gene annotation and interpretation of proteomics data. Here we present JUMPg, an integrative proteogenomics pipeline including customized database construction, tag-based database search, peptide-spectrum match filtering, and data visualization. JUMP...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-16 | MSV000080641 | MassIVE
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