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MetabolomicsWhat CHO is made of: Variations in the biomass composition of Chinese hamster ovary cell lines

Background: Cell line specific, genome-scale metabolic models enable rigorous and systematic in silico investigation of cellular metabolism. Such models have recently become available for Chinese hamster ovary (CHO) too. However, a key ingredient, namely an experimentally validat...

2020-07-13 | MTBLS1210 | MetaboLights
TranscriptomicsIdentification of microRNAs specific for high producer CHO cell lines
Mature microRNA levels were analyzed in 4 producing CHO cell lines expressing 2 structurally different recombinant proteins at low and high level as well as in 1 non-producing CHO cell line. The goal was to identify microRNAs that are involved in heterologous protein formation and secretion. 5 recom...
ORGANISM(S): Cricetulus griseus 
2014-08-04 | E-GEOD-57023 | biostudies-arrayexpress
ProteomicsComparative label-free proteomic analysis of multiple CHO cell lines under tunicamycin-induced ER stress and proteasome inhibition
Chinese Hamster Ovary (CHO) cells are widely utilised in the biopharmaceutical industry to produce therapeutic proteins. Understanding the mechanisms of endoplasmic reticulum (ER) stress and its interplay with protein degradation pathways remains pivotal for improving production efficiency and produ...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2026-08-17 | PXD069782 | Pride
Stress Tunicamycin Cho Lc-ms/ms 
UnknownSimple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes.
Not available
S-EPMC8690173 | biostudies-literature
UnknownBiodegradability of poly(ester-thioether)s containing chiral biomass <i>via</i> a Michael-type thiol-ene click reaction.
Not available
S-EPMC12004360 | biostudies-literature
UnknownAn artificial metallolyase with pliable 2-His-1-carboxylate facial triad for stereoselective Michael addition.
Not available
S-EPMC10074404 | biostudies-literature
UnknownNew Hybrid-type Squaramide-Fused Amino Alcohol Organocatalyst for Enantioselective Domino Michael Addition/Cyclization Reaction of Oxoindolines with Cyclic 1,3-Diketones.
Not available
S-EPMC6645594 | biostudies-literature
TranscriptomicsDifferential gene expression profiles between myeloid-biased and lymphoid-biased hematopoietic stem cells.
Array analysis of My-bi and Ly-bi HSC identifies candidate molecules for myeloid-bias. Collectively the data show that HSC in adults are largely epigenetically fixed in differentiation and self-renewal behavior. A direct examination of the epigenetic mechanisms that imprint HSC is difficult. However...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-41702 | biostudies-arrayexpress
UnknownATP13A3 is a major component of the enigmatic mammalian polyamine transport system.
Not available
S-EPMC7948421 | biostudies-literature
UnknownA low carbohydrate diet high in fish oil and soy protein delays inflammation, hematopoietic stem cell depletion, and mortality in miR-146a knock-out mice.
Not available
S-EPMC9729559 | biostudies-literature
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