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MetabolomicsSnail reprograms glucose metabolism by repressing PFKP allowing cancer cell survival under metabolic stress
Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP) during epithelial-mesenchymal transition (EMT) is not well-understood. Here we show that Snail (SNAI1), a key transcriptional repressor of EMT, regulates glucose flux toward PPP, allowing cancer cel...
2017-11-07 | MTBLS387 | MetaboLights
TranscriptomicsGene expression data from medulloblastoma tumor samples
Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large coh...
ORGANISM(S): Homo sapiens 
2014-06-02 | E-GEOD-49243 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human breast cancer MCF-7 cells treated with 17-AAG
17-AAG treatment of MCF-7 Microarray

Files containing additional statistical analysis and data for meta-probesets are available on the FTP site for the experiment, in E-MTAB-339.additional.zip
ORGANISM(S): Homo sapiens 
2011-08-18 | E-MTAB-339 | biostudies-arrayexpress
TranscriptomicsRNA-Seq on Illumina platform of Drosophila DrosDel deficiency lines
RNA-Seq reads of DrosDel deficiency (Df/+) and parental strain diploid flies along with spike-in controls was performed on the Illumina platform. Samples are named in this dataset according to the following sample naming scheme: tissue_genotype shorthand_sex_biological replicate #_platform. We seque...
ORGANISM(S): Drosophila melanogaster 
2012-04-03 | E-GEOD-31549 | biostudies-arrayexpress
TranscriptomicsMethylation profiling data from medulloblastoma tumor samples
Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large coh...
ORGANISM(S): Homo sapiens 
2014-09-02 | E-GEOD-49377 | biostudies-arrayexpress
TranscriptomicsMethylation data from medulloblastoma tumor samples
Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large coh...
ORGANISM(S): Homo sapiens 
2014-09-02 | E-GEOD-49576 | biostudies-arrayexpress
TranscriptomicsRNA-seq of P. vivax parasite populations, enriched for cytoadhesion and rosetting phenotypes, from vivax malaria patients with scarce parasitemia from the low transmission Brazilian Amazonian endemic region
Deep sequencing of the transcriptome of P. vivax parasite populations from vivax malaria patients with scarce parasitemia from the low transmission Brazilian Amazonian endemic region we the aim of better understanding the molecular mechanisms behind this cytoadherence and rosetting phenotypes by ide...
ORGANISM(S): Homo sapiens 
2024-12-31 | E-MTAB-8385 | biostudies-arrayexpress
UnknownlncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.
Not available
S-EPMC6143179 | biostudies-literature
UnknownDevelopment of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer.
Not available
S-EPMC11009648 | biostudies-literature
TranscriptomicsFunctional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms
We characterized the functions of the understudied LUC7-like family of splicing factors in human cells using seCLIP-seq, RBP knockdown followed by RNA-seq, and Co-IP mass spectrometry.
ORGANISM(S): Homo sapiens 
2021-04-14 | E-MTAB-9709 | biostudies-arrayexpress
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