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ProteomicsEarly retinal synaptic dysfunction and proteomic remodeling precede neurodegeneration in a Parkinson’s disease model
Parkinson’s disease (PD) affects motor and non-motor systems, but retinal changes and their molecular basis are not well understood. Using a transgenic mouse model overexpressing A53T-mutant human α-synuclein, we examined retinal function, structure, and proteomics at 6 and 16 months. Early retinal ...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD066087 | Pride
Visual dysfunction Retina Parkinson's disease Proteomics 
ProteomicsAmplified fluorogenic immunoassay for early diagnosis and monitoring of Alzheimer’s disease from tear fluid
Accurate diagnosis of Alzheimer’s disease (AD) in its earliest stage can prevent the disease and delay the onset of symptoms by maintaining a healthy lifestyle and controlling modifiable risk factors. Therefore, more sensitive, relatively inexpensive, non-invasive, and simple screening tools are req...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042142 | Pride
Alzheimer’s disease Immunoassay Magnetic nanoparticles Polymeric nanoprobes Tear fluid 
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