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ProteomicsRNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway
mRNA level is controlled by factors that mediate both mRNA synthesis and decay, including the 5’ to 3’ exonuclease Xrn1 - a major mRNA synthesis and decay factor. Here we show that nucleocytoplasmic shuttling of several mRNA decay factors plays a key role in determining both mRNA synthesis and decay...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-09-19 | PXD036414 | Pride
Nucleocytoplasmic shuttling Xrn1 Mrna decay 
TranscriptomicsGenomic Run-On (GRO): determination of the nascent transcriptional rate and mRNA amount in Xrn1 mutants
Maintaining the proper mRNA levels is a key aspect in the regulation of gene expression. The balance between mRNA synthesis and decay determines these levels. Using a whole-genome analysis, we demonstrate that most yeast mRNAs are degraded by the 5'-to-3' pathway (the "decaysome"), as prop...
ORGANISM(S): Saccharomyces cerevisiae 
2013-05-22 | E-GEOD-29519 | biostudies-arrayexpress
GenomicsGene expression is a circular process
This study involves the role of yeast mRNA decay factors in transcription. The experiment included here are the ChIP-exo results of three decay factors: Xrn1, Dcp2 & Lsm1. Four experiments were made: Xrn1, Dcp2, Lsm1 and control (no-TAP tag), in two replicates.
ORGANISM(S): Saccharomyces cerevisiae 
2013-05-23 | E-GEOD-44312 | biostudies-arrayexpress
TranscriptomicsGenomic Run On (GRO): determination of the nascent transcriptional rates and mRNA levels in several yeast mutants.
In order to maintain the appropriate level of mRNA it is necessary coordinate simultaneously all the steps along the mRNA life cycle. It has been shown that several factors act in the regulation of gene expression as global coordinators. Thus, some kind of information is transferred from the nucleus...
ORGANISM(S): Saccharomyces cerevisiae 
2015-12-31 | E-GEOD-57467 | biostudies-arrayexpress
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