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TranscriptomicsGenome-wide analyses of XRN1-sensitive targets in osteosarcoma cells identifies disease-relevant transcripts containing G-rich motifs
RNA-seq of ribosome depleted RNA extracted from SAOS-2 cells following treatment with either XRN1 siRNA or a scrambled siRNA control
ORGANISM(S): Homo sapiens 
2021-08-16 | E-MTAB-10808 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of mRNA degradation reveals Xrn1-dependent buffering of transcript levels
The rates of mRNA synthesis and degradation determine cellular mRNA levels and can be monitored by comparative Dynamic Transcriptome Analysis (cDTA) that uses non-perturbing metabolic RNA labeling. Here we present cDTA data for 46 yeast strains lacking genes involved in mRNA degradation and metaboli...
ORGANISM(S): Schizosaccharomyces pombe 
2013-10-18 | E-MTAB-1525 | biostudies-arrayexpress
TranscriptomicsIn-vivo and in-vitro RIP-seq of WT and Delta NLS1/2 mutant of Xrn1
To examine whether the mutations in NLS1/2 affect the interaction with mRNAs, we determined the in vitro and in vivo interaction of WT Xrn1 and Xrn1 Delta NLS1/2 mutant with cellular mRNAs.
ORGANISM(S): Saccharomyces cerevisiae 
2022-08-29 | E-MTAB-12110 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast wild type, xrn1, xrn1 upf1, xrn1 nmd2, and xrn1 upf3 strains to investigate mRNA decay
To determine the effects of inactivation of both the nosense-mediated mRNA decay pathway and the general 5' to 3' decay pathway on yeast mRNA decay, we compared the expression profiles of the wild-type, xrn1, xrn1 upf1, xrn1 nmd2, and xrn1 upf3 strains.
ORGANISM(S): Saccharomyces cerevisiae 
2011-11-08 | E-MEXP-27 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of null Pacman/Xrn1 mutant Drosophila L3 wing imaginal discs
Two pcm null alleles (pcm14 and pcm15) were sequenced alongside respective wild-type controls (wild-type 1 and wild-type 2). Each genotype was replicated 3 times. Read depth was 12-17 million reads per replicate. Total RNA was prepared from Drosophila L3 larval wing imaginal discs.
ORGANISM(S): Drosophila melanogaster 
2016-07-03 | E-MTAB-3789 | biostudies-arrayexpress
ProteomicsXrn1 biochemically associates to the eisosome after the post diauxic shift in yeast
mRNA degradation is one of the main steps of gene expression, and a key player is the 5’-3’ exonuclease Xrn1. In Saccharomyces cerevisiae, it was previously shown, by a microscopy approach, that Xrn1 is located to different cellular compartments, depending on physiological state. During exponential ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-09-15 | PXD044514 | Pride
Affinity purification Xrn1 Post diauxic shift Eisosome Saccharomyces cerevisiae 
ProteomicsXrn1 biochemically associates to the eisosome after the post diauxic shift in yeast (3)
mRNA degradation is one of the main steps of gene expression, and a key player is the 5’-3’ exonuclease Xrn1. In Saccharomyces cerevisiae, it was previously shown, by a microscopy approach, that Xrn1 is located to different cellular compartments, depending on physiological state. During exponential ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-09-15 | PXD044634 | Pride
Affinity purification Xrn1 Post diauxic shift Eisosome Saccharomyces cerevisiae 
ProteomicsXrn1 biochemically associates to the eisosome after the post diauxic shift in yeast (4)
mRNA degradation is one of the main steps of gene expression, and a key player is the 5’-3’ exonuclease Xrn1. In Saccharomyces cerevisiae, it was previously shown, by a microscopy approach, that Xrn1 is located to different cellular compartments, depending on physiological state. During exponential ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-09-15 | PXD044653 | Pride
Affinity purification Xrn1 Post diauxic shift Eisosome Saccharomyces cerevisiae 
ProteomicsXrn1 biochemically associates to the eisosome after the post diauxic shift in yeast (2)
mRNA degradation is one of the main steps of gene expression, and a key player is the 5’-3’ exonuclease Xrn1. In Saccharomyces cerevisiae, it was previously shown, by a microscopy approach, that Xrn1 is located to different cellular compartments, depending on physiological state. During exponential ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-09-15 | PXD044631 | Pride
Xrn1 biochemically associates to the eisosome after the post diauxic shift in yeast 
GenomicsSilencing Xrn1 by dox-inducible shRNA
Silencing Xrn1 by dox-inducible shRNA
PRJNA471893 | ENA
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